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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Mortality in patients with Chronic Hepatitis C and cirrhosis compared to the general population - a Danish cohort study

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BACKGROUND:  Knowledge of mortality in patients with Chronic Hepatitis C (CHC) with cirrhosis is limited. This study aimed to estimate all-cause mortality among CHC patients with and without cirrhosis in Denmark compared to the general population.

METHODS:  Patients registered in The Danish Database for Hepatitis B and C with CHC and a liver fibrosis assessment were eligible for inclusion. Liver fibrosis was based on liver biopsy, transient elastography, and clinical cirrhosis. Up to 20 sex- and age-matched individuals per patient were identified in the general population. Data were extracted from nationwide registries.

RESULTS:  3,410 CHC patients (1,014 with cirrhosis), and 67,315 matched individuals were included. Adjusted mortality rate ratios (MRR) between patients with and without cirrhosis and their comparison cohorts were 5.64 [CI95% 4.76; 6.67] and 1.94 [1.55; 2.42], respectively. Cirrhosis among patients was associated with a MRR of 4.03 [3.43; 4.72]. A cure for CHC was associated with a MRR of 0.64 [0.40; 1.01] among cirrhotic patients and 2.33 [1.47; 3.67] compared to the general population.

CONCLUSIONS:  Mortality was high among CHC patients with and without cirrhosis compared to the general population. Curing CHC was associated with reduced mortality among cirrhotic patients but remained higher than the general population.

Original languageEnglish
JournalThe Journal of infectious diseases
Volume215
Issue number2
Pages (from-to)192-201
ISSN0022-1899
DOIs
Publication statusPublished - Jan 2017

ID: 49164018