Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Morbidity and mortality of nonepileptic seizures (NES): A controlled national study

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Why are antiepileptic drugs continued after successful epilepsy surgery in adults?

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Psychogenic nonepileptic seizures treated with psychotherapy: Long-term outcome on seizures and healthcare utilization

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Welfare consequences for people diagnosed with nonepileptic seizures: A matched nationwide study in Denmark

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. An explorative literature review of the multifactorial causes of osteoporosis in epilepsy

    Research output: Contribution to journalReviewResearchpeer-review

  1. Robust, ECG-based detection of Sleep-disordered breathing in large population-based cohorts

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Long-term health and socioeconomic consequences of childhood and adolescent-onset of narcolepsy

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. The role of sleep in the pathophysiology of nocturnal enuresis

    Research output: Contribution to journalReviewResearchpeer-review

  4. CD8+ T cells from patients with narcolepsy and healthy controls recognize hypocretin neuron-specific antigens

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

Nonepileptic seizures (NES, psychogenic NES-PNES) are associated with significant morbidities. We evaluated the morbidities and mortality in a national group of children, adolescent, and adult patients before and after a first diagnosis of PNES.

METHODS: From the Danish National Patient Registry (1998-2013), we identified 1057 people of all ages with a diagnosis of NES and matched them with 2113 control individuals by age, gender, and geography. Comorbidities were calculated three years before and after diagnoses.

RESULTS: Patients with PNES showed increased comorbidities 3 years before and after diagnosis in almost all the diagnostic domains. The strongest associations were identified with other neurological diseases (after diagnosis, Hazard Ratio (HR): 38.63; 95% Confidence Interval (CI): 21.58-69.13; P < 0.001), abnormal clinical and laboratory findings (HR: 46.59; 95 CI: 27.30-79.52; P < 0.001), other health-related factors (HR: 12.83; 95%CI: 8.45-19.46; P < 0.001), and psychiatric comorbidities (HR: 15.45; 95% CI: 9.81-24.33). Epilepsy was identified in 8% of the patients with PNES. We found especially frequent comorbidity involving overweight, depression, anxiety, dissociative somatoform condition, other convulsions, lipothymias, reports of pain and other symptoms in several organ systems, and several reports of minimal traumas to the head, trunk, and extremities. Mortality was higher in patients with NES than in controls (HR: 3.21; 95% CI: 1.92-5.34; P < 0.001).

CONCLUSION: Morbidity is more frequent in several domains, including neurological, psychiatric, and other diseases, before and after a diagnosis of NES. Mortality is significantly higher in patients with PNES as compared to controls.

Original languageEnglish
JournalEpilepsy and Behavior
Volume96
Pages (from-to)229-233
Number of pages5
ISSN1525-5050
DOIs
Publication statusPublished - Jul 2019

ID: 59153361