Monoklonal gammopati med ubestemt signifikans

Niels Emil Ulrich Hermansen; Trine Silkjær; Charlotte Toftmann Hansen; Thomas Granum Aagaard; Henrik Gregersen

Monoklonal gammopati med ubestemt signifikans

Translated title of the contribution: Monoclonal gammopathy of undetermined significance

Niels Emil Ulrich Hermansen, Trine Silkjær, Charlotte Toftmann Hansen, Thomas Granum Aagaard, Henrik Gregersen

Abstract

This review summarises the work-up of patients with monoclonal gammopathy of undetermined significance (MGUS). In persons above 70 years of age, around 5% have MGUS, a premalignant state with a monoclonal plasma immunoglobulin or light chain (M protein) in blood and/or urine. Continuous follow-up is recommended due to a risk of malignant progression of around 1% per year. Immunoglobulin M MGUS primarily progresses to Waldenström's macroglobulinaemia, whereas non-immunoglobulin M MGUS typically progresses to multiple myeloma or amyloid light-chain amyloidosis. Treatment is unnecessary unless in rare cases of severe non-malignant complications. Screening is not advised.

Translated title of the contribution	Monoclonal gammopathy of undetermined significance
Original language	Danish
Article number	V08190428
Journal	Ugeskrift for Laeger
Volume	182
Issue number	10
Number of pages	5
ISSN	0041-5782
Publication status	Published - 2 Mar 2020
Externally published	Yes

Cite this

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title = "Monoklonal gammopati med ubestemt signifikans",

abstract = "This review summarises the work-up of patients with monoclonal gammopathy of undetermined significance (MGUS). In persons above 70 years of age, around 5% have MGUS, a premalignant state with a monoclonal plasma immunoglobulin or light chain (M protein) in blood and/or urine. Continuous follow-up is recommended due to a risk of malignant progression of around 1% per year. Immunoglobulin M MGUS primarily progresses to Waldenstr{\"o}m's macroglobulinaemia, whereas non-immunoglobulin M MGUS typically progresses to multiple myeloma or amyloid light-chain amyloidosis. Treatment is unnecessary unless in rare cases of severe non-malignant complications. Screening is not advised.",

keywords = "Humans, Immunoglobulin Light-chain Amyloidosis, Monoclonal Gammopathy of Undetermined Significance/diagnosis, Multiple Myeloma, Waldenstrom Macroglobulinemia/diagnosis",

author = "Hermansen, {Niels Emil Ulrich} and Trine Silkj{\ae}r and Hansen, {Charlotte Toftmann} and Aagaard, {Thomas Granum} and Henrik Gregersen",

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TY - JOUR

T1 - Monoklonal gammopati med ubestemt signifikans

AU - Hermansen, Niels Emil Ulrich

AU - Silkjær, Trine

AU - Hansen, Charlotte Toftmann

AU - Aagaard, Thomas Granum

AU - Gregersen, Henrik

PY - 2020/3/2

Y1 - 2020/3/2

N2 - This review summarises the work-up of patients with monoclonal gammopathy of undetermined significance (MGUS). In persons above 70 years of age, around 5% have MGUS, a premalignant state with a monoclonal plasma immunoglobulin or light chain (M protein) in blood and/or urine. Continuous follow-up is recommended due to a risk of malignant progression of around 1% per year. Immunoglobulin M MGUS primarily progresses to Waldenström's macroglobulinaemia, whereas non-immunoglobulin M MGUS typically progresses to multiple myeloma or amyloid light-chain amyloidosis. Treatment is unnecessary unless in rare cases of severe non-malignant complications. Screening is not advised.

AB - This review summarises the work-up of patients with monoclonal gammopathy of undetermined significance (MGUS). In persons above 70 years of age, around 5% have MGUS, a premalignant state with a monoclonal plasma immunoglobulin or light chain (M protein) in blood and/or urine. Continuous follow-up is recommended due to a risk of malignant progression of around 1% per year. Immunoglobulin M MGUS primarily progresses to Waldenström's macroglobulinaemia, whereas non-immunoglobulin M MGUS typically progresses to multiple myeloma or amyloid light-chain amyloidosis. Treatment is unnecessary unless in rare cases of severe non-malignant complications. Screening is not advised.

KW - Humans

KW - Immunoglobulin Light-chain Amyloidosis

KW - Monoclonal Gammopathy of Undetermined Significance/diagnosis

KW - Multiple Myeloma

KW - Waldenstrom Macroglobulinemia/diagnosis

M3 - Review

C2 - 32138824

SN - 0041-5782

VL - 182

JO - Ugeskrift for Laeger

JF - Ugeskrift for Laeger

IS - 10

M1 - V08190428

ER -

Monoklonal gammopati med ubestemt signifikans

Abstract

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