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Molecular Epidemiology and Evolutionary Trajectory of Emerging Echovirus 30, Europe

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Harvard

Benschop, KSM, Broberg, EK, Hodcroft, E, Schmitz, D, Albert, J, Baicus, A, Bailly, J-L, Baldvinsdottir, G, Berginc, N, Blomqvist, S, Böttcher, S, Brytting, M, Bujaki, E, Cabrerizo, M, Celma, C, Cinek, O, Claas, ECJ, Cremer, J, Dean, J, Dembinski, JL, Demchyshyna, I, Diedrich, S, Dudman, S, Dunning, J, Dyrdak, R, Emmanouil, M, Farkas, A, De Gascun, C, Fournier, G, Georgieva, I, Gonzalez-Sanz, R, van Hooydonk-Elving, J, Jääskeläinen, AJ, Jancauskaite, R, Keeren, K, Fischer, TK, Krokstad, S, Nikolaeva-Glomb, L, Novakova, L, Midgley, SE, Mirand, A, Molenkamp, R, Morley, U, Mossong, J, Muralyte, S, Murk, J-L, Nguyen, T, Nordbø, SA, Österback, R, Pas, S, Pellegrinelli, L, Pogka, V, Prochazka, B, Rainetova, P, Van Ranst, M, Roorda, L, Schuffenecker, I, Schuurman, R, Stoyanova, A, Templeton, K, Verweij, JJ, Voulgari-Kokota, A, Vuorinen, T, Wollants, E, Wolthers, KC, Zakikhany, K, Neher, R, Harvala, H & Simmonds, P 2021, 'Molecular Epidemiology and Evolutionary Trajectory of Emerging Echovirus 30, Europe', Emerging Infectious Diseases , vol. 27, no. 6, pp. 1616-1626. https://doi.org/10.3201/eid2706.203096

APA

Benschop, K. S. M., Broberg, E. K., Hodcroft, E., Schmitz, D., Albert, J., Baicus, A., Bailly, J-L., Baldvinsdottir, G., Berginc, N., Blomqvist, S., Böttcher, S., Brytting, M., Bujaki, E., Cabrerizo, M., Celma, C., Cinek, O., Claas, E. C. J., Cremer, J., Dean, J., ... Simmonds, P. (2021). Molecular Epidemiology and Evolutionary Trajectory of Emerging Echovirus 30, Europe. Emerging Infectious Diseases , 27(6), 1616-1626. https://doi.org/10.3201/eid2706.203096

CBE

Benschop KSM, Broberg EK, Hodcroft E, Schmitz D, Albert J, Baicus A, Bailly J-L, Baldvinsdottir G, Berginc N, Blomqvist S, Böttcher S, Brytting M, Bujaki E, Cabrerizo M, Celma C, Cinek O, Claas ECJ, Cremer J, Dean J, Dembinski JL, Demchyshyna I, Diedrich S, Dudman S, Dunning J, Dyrdak R, Emmanouil M, Farkas A, De Gascun C, Fournier G, Georgieva I, Gonzalez-Sanz R, van Hooydonk-Elving J, Jääskeläinen AJ, Jancauskaite R, Keeren K, Fischer TK, Krokstad S, Nikolaeva-Glomb L, Novakova L, Midgley SE, Mirand A, Molenkamp R, Morley U, Mossong J, Muralyte S, Murk J-L, Nguyen T, Nordbø SA, Österback R, Pas S, Pellegrinelli L, Pogka V, Prochazka B, Rainetova P, Van Ranst M, Roorda L, Schuffenecker I, Schuurman R, Stoyanova A, Templeton K, Verweij JJ, Voulgari-Kokota A, Vuorinen T, Wollants E, Wolthers KC, Zakikhany K, Neher R, Harvala H, Simmonds P. 2021. Molecular Epidemiology and Evolutionary Trajectory of Emerging Echovirus 30, Europe. Emerging Infectious Diseases . 27(6):1616-1626. https://doi.org/10.3201/eid2706.203096

MLA

Vancouver

Benschop KSM, Broberg EK, Hodcroft E, Schmitz D, Albert J, Baicus A et al. Molecular Epidemiology and Evolutionary Trajectory of Emerging Echovirus 30, Europe. Emerging Infectious Diseases . 2021 Jun;27(6):1616-1626. https://doi.org/10.3201/eid2706.203096

Author

Benschop, Kimberley S M ; Broberg, Eeva K ; Hodcroft, Emma ; Schmitz, Dennis ; Albert, Jan ; Baicus, Anda ; Bailly, Jean-Luc ; Baldvinsdottir, Gudrun ; Berginc, Natasa ; Blomqvist, Soile ; Böttcher, Sindy ; Brytting, Mia ; Bujaki, Erika ; Cabrerizo, Maria ; Celma, Cristina ; Cinek, Ondrej ; Claas, Eric C J ; Cremer, Jeroen ; Dean, Jonathan ; Dembinski, Jennifer L ; Demchyshyna, Iryna ; Diedrich, Sabine ; Dudman, Susanne ; Dunning, Jake ; Dyrdak, Robert ; Emmanouil, Mary ; Farkas, Agnes ; De Gascun, Cillian ; Fournier, Guillaume ; Georgieva, Irina ; Gonzalez-Sanz, Ruben ; van Hooydonk-Elving, Jolanda ; Jääskeläinen, Anne J ; Jancauskaite, Ruta ; Keeren, Kathrin ; Fischer, Thea K ; Krokstad, Sidsel ; Nikolaeva-Glomb, Lubomira ; Novakova, Ludmila ; Midgley, Sofie E ; Mirand, Audrey ; Molenkamp, Richard ; Morley, Ursula ; Mossong, Joël ; Muralyte, Svajune ; Murk, Jean-Luc ; Nguyen, Trung ; Nordbø, Svein A ; Österback, Riikka ; Pas, Suzan ; Pellegrinelli, Laura ; Pogka, Vassiliki ; Prochazka, Birgit ; Rainetova, Petra ; Van Ranst, Marc ; Roorda, Lieuwe ; Schuffenecker, Isabelle ; Schuurman, Rob ; Stoyanova, Asya ; Templeton, Kate ; Verweij, Jaco J ; Voulgari-Kokota, Androniki ; Vuorinen, Tytti ; Wollants, Elke ; Wolthers, Katja C ; Zakikhany, Katherina ; Neher, Richard ; Harvala, Heli ; Simmonds, Peter. / Molecular Epidemiology and Evolutionary Trajectory of Emerging Echovirus 30, Europe. In: Emerging Infectious Diseases . 2021 ; Vol. 27, No. 6. pp. 1616-1626.

Bibtex

@article{aece57100c05429a967c1ce012708dfd,
title = "Molecular Epidemiology and Evolutionary Trajectory of Emerging Echovirus 30, Europe",
abstract = "In 2018, an upsurge in echovirus 30 (E30) infections was reported in Europe. We conducted a large-scale epidemiologic and evolutionary study of 1,329 E30 strains collected in 22 countries in Europe during 2016-2018. Most E30 cases affected persons 0-4 years of age (29%) and 25-34 years of age (27%). Sequences were divided into 6 genetic clades (G1-G6). Most (53%) sequences belonged to G1, followed by G6 (23%), G2 (17%), G4 (4%), G3 (0.3%), and G5 (0.2%). Each clade encompassed unique individual recombinant forms; G1 and G4 displayed >2 unique recombinant forms. Rapid turnover of new clades and recombinant forms occurred over time. Clades G1 and G6 dominated in 2018, suggesting the E30 upsurge was caused by emergence of 2 distinct clades circulating in Europe. Investigation into the mechanisms behind the rapid turnover of E30 is crucial for clarifying the epidemiology and evolution of these enterovirus infections.",
keywords = "Echovirus Infections, Enterovirus B, Human/genetics, Enterovirus Infections, Europe, Genotype, Humans, Molecular Epidemiology, Phylogeny, Sequence Analysis, DNA",
author = "Benschop, {Kimberley S M} and Broberg, {Eeva K} and Emma Hodcroft and Dennis Schmitz and Jan Albert and Anda Baicus and Jean-Luc Bailly and Gudrun Baldvinsdottir and Natasa Berginc and Soile Blomqvist and Sindy B{\"o}ttcher and Mia Brytting and Erika Bujaki and Maria Cabrerizo and Cristina Celma and Ondrej Cinek and Claas, {Eric C J} and Jeroen Cremer and Jonathan Dean and Dembinski, {Jennifer L} and Iryna Demchyshyna and Sabine Diedrich and Susanne Dudman and Jake Dunning and Robert Dyrdak and Mary Emmanouil and Agnes Farkas and {De Gascun}, Cillian and Guillaume Fournier and Irina Georgieva and Ruben Gonzalez-Sanz and {van Hooydonk-Elving}, Jolanda and J{\"a}{\"a}skel{\"a}inen, {Anne J} and Ruta Jancauskaite and Kathrin Keeren and Fischer, {Thea K} and Sidsel Krokstad and Lubomira Nikolaeva-Glomb and Ludmila Novakova and Midgley, {Sofie E} and Audrey Mirand and Richard Molenkamp and Ursula Morley and Jo{\"e}l Mossong and Svajune Muralyte and Jean-Luc Murk and Trung Nguyen and Nordb{\o}, {Svein A} and Riikka {\"O}sterback and Suzan Pas and Laura Pellegrinelli and Vassiliki Pogka and Birgit Prochazka and Petra Rainetova and {Van Ranst}, Marc and Lieuwe Roorda and Isabelle Schuffenecker and Rob Schuurman and Asya Stoyanova and Kate Templeton and Verweij, {Jaco J} and Androniki Voulgari-Kokota and Tytti Vuorinen and Elke Wollants and Wolthers, {Katja C} and Katherina Zakikhany and Richard Neher and Heli Harvala and Peter Simmonds",
year = "2021",
month = jun,
doi = "10.3201/eid2706.203096",
language = "English",
volume = "27",
pages = "1616--1626",
journal = "Emerging Infectious Diseases ",
issn = "1080-6040",
publisher = "U.S. Department of Health and Human Services Centers for Disease Control and Prevention",
number = "6",

}

RIS

TY - JOUR

T1 - Molecular Epidemiology and Evolutionary Trajectory of Emerging Echovirus 30, Europe

AU - Benschop, Kimberley S M

AU - Broberg, Eeva K

AU - Hodcroft, Emma

AU - Schmitz, Dennis

AU - Albert, Jan

AU - Baicus, Anda

AU - Bailly, Jean-Luc

AU - Baldvinsdottir, Gudrun

AU - Berginc, Natasa

AU - Blomqvist, Soile

AU - Böttcher, Sindy

AU - Brytting, Mia

AU - Bujaki, Erika

AU - Cabrerizo, Maria

AU - Celma, Cristina

AU - Cinek, Ondrej

AU - Claas, Eric C J

AU - Cremer, Jeroen

AU - Dean, Jonathan

AU - Dembinski, Jennifer L

AU - Demchyshyna, Iryna

AU - Diedrich, Sabine

AU - Dudman, Susanne

AU - Dunning, Jake

AU - Dyrdak, Robert

AU - Emmanouil, Mary

AU - Farkas, Agnes

AU - De Gascun, Cillian

AU - Fournier, Guillaume

AU - Georgieva, Irina

AU - Gonzalez-Sanz, Ruben

AU - van Hooydonk-Elving, Jolanda

AU - Jääskeläinen, Anne J

AU - Jancauskaite, Ruta

AU - Keeren, Kathrin

AU - Fischer, Thea K

AU - Krokstad, Sidsel

AU - Nikolaeva-Glomb, Lubomira

AU - Novakova, Ludmila

AU - Midgley, Sofie E

AU - Mirand, Audrey

AU - Molenkamp, Richard

AU - Morley, Ursula

AU - Mossong, Joël

AU - Muralyte, Svajune

AU - Murk, Jean-Luc

AU - Nguyen, Trung

AU - Nordbø, Svein A

AU - Österback, Riikka

AU - Pas, Suzan

AU - Pellegrinelli, Laura

AU - Pogka, Vassiliki

AU - Prochazka, Birgit

AU - Rainetova, Petra

AU - Van Ranst, Marc

AU - Roorda, Lieuwe

AU - Schuffenecker, Isabelle

AU - Schuurman, Rob

AU - Stoyanova, Asya

AU - Templeton, Kate

AU - Verweij, Jaco J

AU - Voulgari-Kokota, Androniki

AU - Vuorinen, Tytti

AU - Wollants, Elke

AU - Wolthers, Katja C

AU - Zakikhany, Katherina

AU - Neher, Richard

AU - Harvala, Heli

AU - Simmonds, Peter

PY - 2021/6

Y1 - 2021/6

N2 - In 2018, an upsurge in echovirus 30 (E30) infections was reported in Europe. We conducted a large-scale epidemiologic and evolutionary study of 1,329 E30 strains collected in 22 countries in Europe during 2016-2018. Most E30 cases affected persons 0-4 years of age (29%) and 25-34 years of age (27%). Sequences were divided into 6 genetic clades (G1-G6). Most (53%) sequences belonged to G1, followed by G6 (23%), G2 (17%), G4 (4%), G3 (0.3%), and G5 (0.2%). Each clade encompassed unique individual recombinant forms; G1 and G4 displayed >2 unique recombinant forms. Rapid turnover of new clades and recombinant forms occurred over time. Clades G1 and G6 dominated in 2018, suggesting the E30 upsurge was caused by emergence of 2 distinct clades circulating in Europe. Investigation into the mechanisms behind the rapid turnover of E30 is crucial for clarifying the epidemiology and evolution of these enterovirus infections.

AB - In 2018, an upsurge in echovirus 30 (E30) infections was reported in Europe. We conducted a large-scale epidemiologic and evolutionary study of 1,329 E30 strains collected in 22 countries in Europe during 2016-2018. Most E30 cases affected persons 0-4 years of age (29%) and 25-34 years of age (27%). Sequences were divided into 6 genetic clades (G1-G6). Most (53%) sequences belonged to G1, followed by G6 (23%), G2 (17%), G4 (4%), G3 (0.3%), and G5 (0.2%). Each clade encompassed unique individual recombinant forms; G1 and G4 displayed >2 unique recombinant forms. Rapid turnover of new clades and recombinant forms occurred over time. Clades G1 and G6 dominated in 2018, suggesting the E30 upsurge was caused by emergence of 2 distinct clades circulating in Europe. Investigation into the mechanisms behind the rapid turnover of E30 is crucial for clarifying the epidemiology and evolution of these enterovirus infections.

KW - Echovirus Infections

KW - Enterovirus B, Human/genetics

KW - Enterovirus Infections

KW - Europe

KW - Genotype

KW - Humans

KW - Molecular Epidemiology

KW - Phylogeny

KW - Sequence Analysis, DNA

UR - http://www.scopus.com/inward/record.url?scp=85106520894&partnerID=8YFLogxK

U2 - 10.3201/eid2706.203096

DO - 10.3201/eid2706.203096

M3 - Journal article

C2 - 34013874

VL - 27

SP - 1616

EP - 1626

JO - Emerging Infectious Diseases

JF - Emerging Infectious Diseases

SN - 1080-6040

IS - 6

ER -

ID: 66258430