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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Molecular basis of antifungal drug resistance in yeasts

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Besides inherent differences in in vitro susceptibilities, clinically-relevant yeast species may acquire resistance upon exposure to most antifungal drugs used in the clinic. In recent years, major fundamental research studies have been conducted to improve our understanding of the molecular basis of antifungal resistance. This topic is of major interest as antifungal resistance in yeast is clearly evolving and is correlated with clinical failure. This minireview is an overview of the most recent findings about key molecular mechanisms evolving in human pathogenic yeasts, particularly Candida spp., in the context of antifungal drug resistance. Also included are the methods currently available for in vitro antifungal susceptibility testing and for molecular detection of mutations associated with resistance. Finally, the genetic drivers of antifungal resistance are discussed in light of the spectra of multidrug resistance as observed in Candida glabrata.

Original languageEnglish
JournalInternational Journal of Antimicrobial Agents
Volume50
Issue number5
Pages (from-to)599-606
Number of pages8
ISSN0924-8579
DOIs
Publication statusPublished - Nov 2017

    Research areas

  • Journal Article

ID: 52080852