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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Moderate- to high-intensity exercise does not modify cortical β-amyloid in Alzheimer's disease

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Introduction: Animal models of Alzheimer's disease show that exercise may modify β-amyloid (Aβ) deposition. We examined the effect of a 16-week exercise intervention on cortical Aβ in patients with mild-to-moderate Alzheimer's disease.

Methods: Thirty-six patients with Alzheimer's disease were randomized to either one hour of aerobic exercise three times weekly for 16 weeks or usual care. Pre and post intervention, 11Carbon-Pittsburgh compound B positron emission tomography was carried out to assess cortical Aβ, and quantified using standardized uptake value rations (SUVRs).

Results: The intervention showed no effect on follow-up SUVRs in a covariance analysis with group allocation, baseline intervention SUVR, age, sex, and baseline Mini-Mental State Examination as predictors. Change in SUVRs did not correlate with changes in measures of physical or aerobic fitness.

Discussion: The present findings do not support an effect of exercise on Aβ. However, the relatively short intervention period may account for a lack of efficacy. Further studies should test earlier and longer interventions.

Original languageEnglish
JournalAlzheimer's & Dementia: Translational Research & Clinical Interventions
Volume5
Pages (from-to)208-215
Number of pages8
ISSN2352-8737
DOIs
Publication statusPublished - 1 Jan 2019

    Research areas

  • 11C-PiB-PET, Aerobic exercise, Alzheimer's disease, Dementia, Exercise, Intervention, PET, Randomized, β-amyloid

ID: 57376244