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Modeling transfer of vaginal microbiota from mother to infant in early life

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Mortensen, Martin Steen ; Rasmussen, Morten Arendt ; Stokholm, Jakob ; Brejnrod, Asker Daniel ; Balle, Christina ; Thorsen, Jonathan ; Krogfelt, Karen Angeliki ; Bisgaard, Hans ; Sørensen, Søren Johannes. / Modeling transfer of vaginal microbiota from mother to infant in early life. In: eLife. 2021 ; Vol. 10. pp. 1-19.

Bibtex

@article{6bdbab1544c349d4af5bb2e797fa745f,
title = "Modeling transfer of vaginal microbiota from mother to infant in early life",
abstract = "Early-life microbiota has been linked to the development of chronic inflammatory diseases. It has been hypothesized that maternal vaginal microbiota is an important initial seeding source and therefore might have lifelong effects on disease risk. To understand maternal vaginal microbiota's role in seeding the child's microbiota and the extent of delivery mode-dependent transmission, we studied 665 mother-child dyads from the COPSAC2010 cohort. The maternal vaginal microbiota was evaluated twice in the third trimester and compared with the children's fecal (at 1 week, 1 month, and 1 year of age) and airway microbiota (at 1 week, 1 month, and 3 months). Based on the concept of weighted transfer ratios (WTRs), we have identified bacterial orders for which the WTR displays patterns indicate persistent or transient transfer from the maternal vaginal microbiome, as well as orders that are shared at later time points independent of delivery mode, indicating a common reservoir.",
author = "Mortensen, {Martin Steen} and Rasmussen, {Morten Arendt} and Jakob Stokholm and Brejnrod, {Asker Daniel} and Christina Balle and Jonathan Thorsen and Krogfelt, {Karen Angeliki} and Hans Bisgaard and S{\o}rensen, {S{\o}ren Johannes}",
note = "{\textcopyright} 2021, Mortensen et al.",
year = "2021",
month = jan,
day = "15",
doi = "10.7554/ELIFE.57051",
language = "English",
volume = "10",
pages = "1--19",
journal = "eLife",
issn = "2050-084X",
publisher = "eLife Sciences Publications",

}

RIS

TY - JOUR

T1 - Modeling transfer of vaginal microbiota from mother to infant in early life

AU - Mortensen, Martin Steen

AU - Rasmussen, Morten Arendt

AU - Stokholm, Jakob

AU - Brejnrod, Asker Daniel

AU - Balle, Christina

AU - Thorsen, Jonathan

AU - Krogfelt, Karen Angeliki

AU - Bisgaard, Hans

AU - Sørensen, Søren Johannes

N1 - © 2021, Mortensen et al.

PY - 2021/1/15

Y1 - 2021/1/15

N2 - Early-life microbiota has been linked to the development of chronic inflammatory diseases. It has been hypothesized that maternal vaginal microbiota is an important initial seeding source and therefore might have lifelong effects on disease risk. To understand maternal vaginal microbiota's role in seeding the child's microbiota and the extent of delivery mode-dependent transmission, we studied 665 mother-child dyads from the COPSAC2010 cohort. The maternal vaginal microbiota was evaluated twice in the third trimester and compared with the children's fecal (at 1 week, 1 month, and 1 year of age) and airway microbiota (at 1 week, 1 month, and 3 months). Based on the concept of weighted transfer ratios (WTRs), we have identified bacterial orders for which the WTR displays patterns indicate persistent or transient transfer from the maternal vaginal microbiome, as well as orders that are shared at later time points independent of delivery mode, indicating a common reservoir.

AB - Early-life microbiota has been linked to the development of chronic inflammatory diseases. It has been hypothesized that maternal vaginal microbiota is an important initial seeding source and therefore might have lifelong effects on disease risk. To understand maternal vaginal microbiota's role in seeding the child's microbiota and the extent of delivery mode-dependent transmission, we studied 665 mother-child dyads from the COPSAC2010 cohort. The maternal vaginal microbiota was evaluated twice in the third trimester and compared with the children's fecal (at 1 week, 1 month, and 1 year of age) and airway microbiota (at 1 week, 1 month, and 3 months). Based on the concept of weighted transfer ratios (WTRs), we have identified bacterial orders for which the WTR displays patterns indicate persistent or transient transfer from the maternal vaginal microbiome, as well as orders that are shared at later time points independent of delivery mode, indicating a common reservoir.

UR - http://www.scopus.com/inward/record.url?scp=85100010042&partnerID=8YFLogxK

U2 - 10.7554/ELIFE.57051

DO - 10.7554/ELIFE.57051

M3 - Journal article

C2 - 33448927

VL - 10

SP - 1

EP - 19

JO - eLife

JF - eLife

SN - 2050-084X

M1 - e57051

ER -

ID: 62084677