Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Modeling transfer of vaginal microbiota from mother to infant in early life

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Cortical signatures of precision grip force control in children, adolescents, and adults

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Identification of human glucocorticoid response markers using integrated multi-omic analysis from a randomized crossover trial

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Heterogeneous contributions of change in population distribution of body mass index to change in obesity and underweight

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. An open label trial of anakinra to prevent respiratory failure in COVID-19

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Host-induced spermidine production in motile Pseudomonas aeruginosa triggers phagocytic uptake

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. High-Dose Vitamin D During Pregnancy and Pathway Gene Polymorphisms in Prevention of Offspring Persistent Wheeze

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Breast milk n-3 long-chain polyunsaturated fatty acids and blood pressure: an individual participant meta-analysis

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Cost of Illness in Young Children: A Prospective Birth Cohort Study

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Symptom burden of atopic dermatitis in early childhood assessed from daily monitoring of symptoms and topical steroid use

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Asthma-like Symptoms in Young Children Increase the Risk of COPD

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

Early-life microbiota has been linked to the development of chronic inflammatory diseases. It has been hypothesized that maternal vaginal microbiota is an important initial seeding source and therefore might have lifelong effects on disease risk. To understand maternal vaginal microbiota's role in seeding the child's microbiota and the extent of delivery mode-dependent transmission, we studied 665 mother-child dyads from the COPSAC2010 cohort. The maternal vaginal microbiota was evaluated twice in the third trimester and compared with the children's fecal (at 1 week, 1 month, and 1 year of age) and airway microbiota (at 1 week, 1 month, and 3 months). Based on the concept of weighted transfer ratios (WTRs), we have identified bacterial orders for which the WTR displays patterns indicate persistent or transient transfer from the maternal vaginal microbiome, as well as orders that are shared at later time points independent of delivery mode, indicating a common reservoir.

Original languageEnglish
Article numbere57051
JournaleLife
Volume10
Pages (from-to)1-19
Number of pages19
ISSN2050-084X
DOIs
Publication statusPublished - 15 Jan 2021

Bibliographical note

© 2021, Mortensen et al.

ID: 62084677