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Modeling malaria infection and immunity against variant surface antigens in Príncipe Island, West Africa

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  3. Plasmodium falciparum-CD36 Structure-Function Relationships Defined by Ortholog Scanning Mutagenesis

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  • Cátia Bandeiras
  • Maria Jesus Trovoada
  • Lígia A Gonçalves
  • Cláudio R F Marinho
  • Louise Turner
  • Lars Hviid
  • Carlos Penha-Gonçalves
  • M Gabriela M Gomes
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After remarkable success of vector control campaigns worldwide, concerns about loss of immunity against Plasmodium falciparum due to lack of exposure to the parasite are relevant since an increase of severe cases in less immune individuals is expected. We present a mathematical model to investigate the impact of reducing exposure to the parasite on the immune repertoire against P. falciparum erythrocyte membrane protein 1 (PfEMP1) variants. The model was parameterized with data from Príncipe Island, West Africa, and applied to simulate two alternative transmission scenarios: one where control measures are continued to eventually drive the system to elimination; and another where the effort is interrupted after 6 years of its initiation and the system returns to the initial transmission potential. Population dynamics of parasite prevalence predict that in a few years infection levels return to the pre-control values, while the re-acquisition of the immune repertoire against PfEMP1 is slower, creating a window for increased severity. The model illustrates the consequences of loss of immune repertoire against PfEMP1 in a given setting and can be applied to other regions where similar data may be available.

Original languageEnglish
JournalP L o S One
Volume9
Issue number2
Pages (from-to)e88110
ISSN1932-6203
DOIs
Publication statusPublished - 2014

    Research areas

  • Africa, Western, Antibodies, Protozoan, Antigens, Protozoan, Computer Simulation, Genetic Variation, Humans, Immunity, Islands, Malaria, Falciparum, Models, Immunological, Plasmodium falciparum, Prevalence, Protozoan Proteins

ID: 44939404