Model-based closed-loop glucose control in type 1 diabetes: the DiaCon experience

Signe Schmidt; Dimitri Boiroux; Anne Katrine Duun-Henriksen; Laurits Frøssing; Ole Skyggebjerg; John Bagterp Jørgensen; Niels Kjølstad Poulsen; Henrik Tækker Madsen; Sten Madsbad; Kirsten Nørgaard

Model-based closed-loop glucose control in type 1 diabetes: the DiaCon experience

Signe Schmidt, Dimitri Boiroux, Anne Katrine Duun-Henriksen, Laurits Frøssing, Ole Skyggebjerg, John Bagterp Jørgensen, Niels Kjølstad Poulsen, Henrik Tækker Madsen, Sten Madsbad, Kirsten Nørgaard

Endocrinology Unit

33 Citations (Scopus)

Abstract

To improve type 1 diabetes mellitus (T1DM) management, we developed a model predictive control (MPC) algorithm for closed-loop (CL) glucose control based on a linear second-order deterministic-stochastic model. The deterministic part of the model is specified by three patient-specific parameters: insulin sensitivity factor, insulin action time, and basal insulin infusion rate. The stochastic part is identical for all patients but identified from data from a single patient. Results of the first clinical feasibility test of the algorithm are presented.

Original language	English
Journal	Journal of diabetes science and technology
Volume	7
Issue number	5
Pages (from-to)	1255-64
Number of pages	10
ISSN	1932-2968
Publication status	Published - Sept 2013

Cite this

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title = "Model-based closed-loop glucose control in type 1 diabetes: the DiaCon experience",

abstract = "To improve type 1 diabetes mellitus (T1DM) management, we developed a model predictive control (MPC) algorithm for closed-loop (CL) glucose control based on a linear second-order deterministic-stochastic model. The deterministic part of the model is specified by three patient-specific parameters: insulin sensitivity factor, insulin action time, and basal insulin infusion rate. The stochastic part is identical for all patients but identified from data from a single patient. Results of the first clinical feasibility test of the algorithm are presented.",

author = "Signe Schmidt and Dimitri Boiroux and Duun-Henriksen, \{Anne Katrine\} and Laurits Fr{\o}ssing and Ole Skyggebjerg and J{\o}rgensen, \{John Bagterp\} and Poulsen, \{Niels Kj{\o}lstad\} and Madsen, \{Henrik T{\ae}kker\} and Sten Madsbad and Kirsten N{\o}rgaard",

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T1 - Model-based closed-loop glucose control in type 1 diabetes

T2 - the DiaCon experience

AU - Schmidt, Signe

AU - Boiroux, Dimitri

AU - Duun-Henriksen, Anne Katrine

AU - Frøssing, Laurits

AU - Skyggebjerg, Ole

AU - Jørgensen, John Bagterp

AU - Poulsen, Niels Kjølstad

AU - Madsen, Henrik Tækker

AU - Madsbad, Sten

AU - Nørgaard, Kirsten

PY - 2013/9

Y1 - 2013/9

N2 - To improve type 1 diabetes mellitus (T1DM) management, we developed a model predictive control (MPC) algorithm for closed-loop (CL) glucose control based on a linear second-order deterministic-stochastic model. The deterministic part of the model is specified by three patient-specific parameters: insulin sensitivity factor, insulin action time, and basal insulin infusion rate. The stochastic part is identical for all patients but identified from data from a single patient. Results of the first clinical feasibility test of the algorithm are presented.

AB - To improve type 1 diabetes mellitus (T1DM) management, we developed a model predictive control (MPC) algorithm for closed-loop (CL) glucose control based on a linear second-order deterministic-stochastic model. The deterministic part of the model is specified by three patient-specific parameters: insulin sensitivity factor, insulin action time, and basal insulin infusion rate. The stochastic part is identical for all patients but identified from data from a single patient. Results of the first clinical feasibility test of the algorithm are presented.

UR - https://www.scopus.com/pages/publications/84898429386

M3 - Journal article

C2 - 24124952

SN - 1932-2968

VL - 7

SP - 1255

EP - 1264

JO - Journal of diabetes science and technology

JF - Journal of diabetes science and technology

IS - 5

ER -

Model-based closed-loop glucose control in type 1 diabetes: the DiaCon experience

Abstract

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