Mitochondrial 12S Ribosomal RNA A1555G Mutation Associated with Cardiomyopathy and Hearing Loss following High-Dose Chemotherapy and Repeated Aminoglycoside Exposure

Anne-Sofie Skou; Lisbeth Tranebjærg; Tim Jensen; Henrik Hasle

doi:10.1016/j.jpeds.2013.10.024

Mitochondrial 12S Ribosomal RNA A1555G Mutation Associated with Cardiomyopathy and Hearing Loss following High-Dose Chemotherapy and Repeated Aminoglycoside Exposure

Anne-Sofie Skou, Lisbeth Tranebjærg, Tim Jensen, Henrik Hasle

12 Citations (Scopus)

Abstract

A 19-month-old girl with the A1555G mitochondrial mutation in the 12S ribosomal RNA gene and acute myelogenous leukemia developed dilated cardiomyopathy and bilateral sensorineural hearing loss before undergoing allogeneic stem cell transplantation. She had received gentamicin during episodes of febrile neutropenia. Testing for the A1555G mutation is recommended in patients frequently treated with aminoglycosides.

Original language	English
Journal	The Journal of pediatrics
Volume	164
Issue number	2
Pages (from-to)	413-15
ISSN	0022-3476
DOIs	https://doi.org/10.1016/j.jpeds.2013.10.024
Publication status	Published - 2014

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Mitochondrial 12S Ribosomal RNA A1555G Mutation Associated with Cardiomyopathy and Hearing Loss following High-Dose Chemotherapy and Repeated Aminoglycoside Exposure. / Skou, Anne-Sofie; Tranebjærg, Lisbeth ; Jensen, Tim et al.

In: The Journal of pediatrics, Vol. 164, No. 2, 2014, p. 413-15.

Research output: Contribution to journal › Journal article › Research › peer-review

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abstract = "A 19-month-old girl with the A1555G mitochondrial mutation in the 12S ribosomal RNA gene and acute myelogenous leukemia developed dilated cardiomyopathy and bilateral sensorineural hearing loss before undergoing allogeneic stem cell transplantation. She had received gentamicin during episodes of febrile neutropenia. Testing for the A1555G mutation is recommended in patients frequently treated with aminoglycosides.",

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AU - Jensen, Tim

AU - Hasle, Henrik

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AB - A 19-month-old girl with the A1555G mitochondrial mutation in the 12S ribosomal RNA gene and acute myelogenous leukemia developed dilated cardiomyopathy and bilateral sensorineural hearing loss before undergoing allogeneic stem cell transplantation. She had received gentamicin during episodes of febrile neutropenia. Testing for the A1555G mutation is recommended in patients frequently treated with aminoglycosides.

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DO - 10.1016/j.jpeds.2013.10.024

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Mitochondrial 12S Ribosomal RNA A1555G Mutation Associated with Cardiomyopathy and Hearing Loss following High-Dose Chemotherapy and Repeated Aminoglycoside Exposure

Abstract

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