miR-449 inhibits cell proliferation and is down-regulated in gastric cancer

Tony Bou Kheir, Ewa Futoma-Kazmierczak, Anders Martin Bøgild Jacobsen, Anders Stærmose Krogh, Linda Bardram, Christoffer Hother, Kirsten Grønbæk, Birgitte Federspiel, Anders Henrik Lund, Lennart Friis-Hansen

222 Citations (Scopus)

Abstract

Gastric cancer is the fourth most common cancer in the world and the second most prevalent cause of cancer related death. The development of gastric cancer is mainly associated with H. Pylori infection leading to a focus in pathology studies on bacterial and environmental factors, and to a lesser extent on the mechanistic development of the tumour. MicroRNAs are small non-coding RNA molecules involved in post-transcriptional gene regulation. They are found to regulate genes involved in diverse biological functions and alterations in microRNA expression have been linked to the pathogenesis of many malignancies. The current study is focused on identifying microRNAs involved in gastric carcinogenesis and to explore their mechanistic relevance by characterizing their targets.
Original languageEnglish
JournalMolecular Cancer
Volume10
Pages (from-to)29
ISSN1476-4598
DOIs
Publication statusPublished - 2011

Keywords

  • Adenoma
  • Animals
  • Base Sequence
  • Cell Aging
  • Cell Cycle
  • Cell Line, Tumor
  • Cell Proliferation
  • Down-Regulation
  • Gastrins
  • Gene Expression Regulation, Neoplastic
  • Helicobacter Infections
  • Helicobacter pylori
  • Humans
  • Mice
  • Mice, Knockout
  • MicroRNAs
  • Molecular Sequence Data
  • Pyloric Antrum
  • Signal Transduction
  • Stomach Neoplasms
  • Tumor Suppressor Protein p53

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