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Mining the granule proteome: a potential source of endocrine biomarkers

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Proteomics of secretory granules is an emerging strategy for identifying secreted proteins, including potentially novel candidate biomarkers and peptide hormones. In addition, proteomics can provide information about the abundance, localization and structure (post-translational modification) of granule proteins and peptides. Analytical strategies within this research line include so-called 'subtractive proteomics', 'peptidomics' and granule purification by the use of multiple gradient centrifugations. Here we review the literature, and describe the challenges and opportunities in proteomics of secretory granules.

Original languageEnglish
JournalBiomarkers in Medicine
Volume9
Issue number3
Pages (from-to)259-65
Number of pages7
ISSN1752-0363
DOIs
Publication statusPublished - 2015

    Research areas

  • Biomarkers, Endocrine Cells, Humans, Peptides, Proteome, Proteomics, Secretory Vesicles

ID: 45920120