Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
E-pub ahead of print

Minimally invasive assessment of hepatic function in children with indocyanine green elimination: a validation study

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Antibiotics: a risk factor for irritable bowel syndrome in a population-based cohort

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Quality of life, performance status, and work capacity after post-endoscopic retrograde cholangiopancreatography pancreatitis

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Microscopic colitis in Denmark and Sweden: incidence, putative risk factors, histological assessment and endoscopic activity

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Direct acting antiviral treatment of chronic hepatitis C in Denmark: factors associated with and barriers to treatment initiation

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Nutritional status and nutritional risk in patients with neuroendocrine tumors

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Collagen type IV remodelling gender-specifically predicts mortality in decompensated cirrhosis

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Exercise-mediated improvement of depression in patients with gastro-esophageal junction cancer is linked to kynurenine metabolism

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Successful paediatric renography does not require sedation

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

OBJECTIVES: Pediatric liver disease (PLD) covers a variety of etiologies and severities, from mild temporary illness to diseases with fatal outcomes. There is a demand for minimally invasive and reliable measures for assessment of the severity of PLD. Indocyanine green (ICG) elimination kinetics to estimate hepatic function has been used in adults for decades, however, due to invasiveness, the use in PLD is still limited. The aim of the present study was to evaluate minimally invasive estimation of ICG elimination by pulse spectrophotometry (ICGLi), in comparison with traditional spectrophotometry using serial blood samples (ICGbs).

METHODS: One hundred children aged 0-18 years were included in the study. ICG elimination kinetics was measured with ICGLi and ICGbs, and results compared by failure rates, mean difference, limits of agreement, Bland Altman plots and linear regression analysis. Plasma disappearance rates (PDRLi and PDRbs) were used for comparison.

RESULTS: One hundred and twelve simultaneous measurements in 87 patients were performed successfully. Mean difference for PDR (%/min) was 3.58 (95% CI 2.69; 4.47). Limits of agreement were -5.06; 12.22. A linear correlation between the two methods with a regression coefficient of 0.83 (SE 0.02 95% CI 0.80; 0.87) was found. For conversion we computed the following equation; PDRbs = 0.83 × PDRLi.

CONCLUSIONS: The present study shows that ICG PDR can be obtained by a minimally invasive method and thus replace measures by serial blood samples in children with liver disease of different etiologies and severities. However, a systematic relative difference between the two methods exists. Our proposed correction factor needs to be validated in larger cohorts.

Original languageEnglish
JournalScandinavian Journal of Gastroenterology
Pages (from-to)1-7
Number of pages7
ISSN0036-5521
DOIs
Publication statusE-pub ahead of print - 29 Mar 2019

    Research areas

  • autoimmune hepatitis, biliary atresia, indocyanine green, liver function tests, liver transplantation, Pediatric liver disease

ID: 56909157