Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Minimal T-wave representation and its use in the assessment of drug arrhythmogenicity

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Validation of an automatic diagnosis of strict left bundle branch block criteria using 12-lead electrocardiograms

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Heart Rate Variability Density Analysis (Dyx) and Prediction of Long-Term Mortality after Acute Myocardial Infarction

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Specificity of elevated intercostal space ECG recording for the type 1 Brugada ECG pattern

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Reappraisal of variants previously linked with sudden infant death syndrome: results from three population-based cohorts

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Genome-wide association meta-analysis of 30,000 samples identifies seven novel loci for quantitative ECG traits

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Long-term proarrhythmic pharmacotherapy among patients with congenital long QT syndrome and risk of arrhythmia and mortality

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Complex spatio-temporal distribution and genomic ancestry of mitochondrial DNA haplogroups in 24,216 Danes

    Research output: Contribution to journalJournal articleResearchpeer-review

  • Saeed Shakibfar
  • Claus Graff
  • Jørgen K Kanters
  • Jimmi Nielsen
  • Samuel Schmidt
  • Johannes J Struijk
View graph of relations

BACKGROUND: Recently, numerous models and techniques have been developed for analyzing and extracting features from the T wave which could be used as biomarkers for drug-induced abnormalities. The majority of these techniques and algorithms use features that determine readily apparent characteristics of the T wave, such as duration, area, amplitude, and slopes.

METHODS: In the present work the T wave was down-sampled to a minimal rate, such that a good reconstruction was still possible. The entire T wave was then used as a feature vector to assess drug-induced repolarization effects. The ability of the samples or combinations of samples obtained from the minimal T-wave representation to correctly classify a group of subjects before and after receiving d,l-sotalol 160 mg and 320 mg was evaluated using a linear discriminant analysis (LDA).

RESULTS: The results showed that a combination of eight samples from the minimal T-wave representation can be used to identify normal from abnormal repolarization significantly better compared to the heart rate-corrected QT interval (QTc). It was further indicated that the interval from the peak of the T wave to the end of the T wave (Tpe) becomes relatively shorter after IKr inhibition by d,l-sotalol and that the most pronounced repolarization changes were present in the ascending segment of the minimal T-wave representation.

CONCLUSIONS: The minimal T-wave representation can potentially be used as a new tool to identify normal from abnormal repolarization in drug safety studies.

Original languageEnglish
JournalAnnals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc
Volume22
Issue number3
ISSN1542-474X
DOIs
Publication statusPublished - May 2017

    Research areas

  • Journal Article

ID: 52628211