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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Migration of an outer retinal element in a healthy child followed by longitudinal multimodal imaging

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  2. Progression Over 5 Years of Prelaminar Hyperreflective Lines to Optic Disc Drusen in the Copenhagen Child Cohort 2000 Eye Study

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Purpose: To describe the migration of an outer retinal element using longitudinal multimodal imaging.

Observations: In the retina of a healthy 7-year-old girl, movement of a hyperreflective element of 15 μm extent was seen using optical coherence tomography (OCT), confocal scanning laser ophthalmoscopy (cSLO), and adaptive optics fundus photography (AO). On the OCT B-scan, the element initially appeared at the level of the outer limiting membrane with an umbra reaching the retinal pigment epithelium from where it gradually diminished and disappeared over 33 days. A corresponding disruption of the photoreceptor pattern on AO diminished over 52 days.

Conclusions and importance: This non-invasive observation of an isolated, cell-sized, migrating element in the human retina was made in vivo in the absence of confounding retinal disease or similar nearby elements. Based on prior preclinical observations we hypothesize that such a migrating element could be a macrophage. The case provides information about the time-scale and resolution needed for the monitoring of infiltrative processes in the retina.

Original languageEnglish
JournalAmerican Journal of Ophthalmology Case Reports
Volume18
Pages (from-to)100637
ISSN2451-9936
DOIs
Publication statusPublished - Jun 2020

ID: 62051791