Migraine headache and aura induced by hypoxia

Mohammad Al-Mahdi Al-Karagholi; Nanna Arngrim; Messoud Ashina

doi:10.1113/JP284553

Migraine headache and aura induced by hypoxia

Mohammad Al-Mahdi Al-Karagholi, Nanna Arngrim, Messoud Ashina^*

^*Corresponding author for this work

Department of Neurology

1 Citation (Scopus)

Abstract

Migraine, a common neurological disorder, impacts over a billion individuals globally. Its complex aetiology involves various signalling cascades. Hypoxia causes headaches such as high-altitude headache and acute mountain sickness which share phenotypical similarities with migraine. Epidemiological data indicate an increased prevalence of migraine with and without aura in high-altitude populations. Experimental studies have further shown that hypoxia can induce migraine attacks. This review summarizes evidence linking hypoxia to migraine, delves into potential pathophysiological mechanisms and highlights research gaps.

Original language	English
Journal	The Journal of physiology
Volume	602
Issue number	21
Pages (from-to)	5515-5522
Number of pages	8
ISSN	0022-3751
DOIs	https://doi.org/10.1113/JP284553
Publication status	Published - Nov 2024

Keywords

Altitude Sickness/physiopathology
Animals
Humans
Hypoxia/physiopathology
Migraine Disorders/physiopathology
Migraine with Aura/physiopathology

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10.1113/JP284553

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title = "Migraine headache and aura induced by hypoxia",

abstract = "Migraine, a common neurological disorder, impacts over a billion individuals globally. Its complex aetiology involves various signalling cascades. Hypoxia causes headaches such as high-altitude headache and acute mountain sickness which share phenotypical similarities with migraine. Epidemiological data indicate an increased prevalence of migraine with and without aura in high-altitude populations. Experimental studies have further shown that hypoxia can induce migraine attacks. This review summarizes evidence linking hypoxia to migraine, delves into potential pathophysiological mechanisms and highlights research gaps.",

keywords = "Altitude Sickness/physiopathology, Animals, Humans, Hypoxia/physiopathology, Migraine Disorders/physiopathology, Migraine with Aura/physiopathology",

author = "Al-Karagholi, {Mohammad Al-Mahdi} and Nanna Arngrim and Messoud Ashina",

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year = "2024",

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doi = "10.1113/JP284553",

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T1 - Migraine headache and aura induced by hypoxia

AU - Al-Karagholi, Mohammad Al-Mahdi

AU - Arngrim, Nanna

AU - Ashina, Messoud

PY - 2024/11

Y1 - 2024/11

N2 - Migraine, a common neurological disorder, impacts over a billion individuals globally. Its complex aetiology involves various signalling cascades. Hypoxia causes headaches such as high-altitude headache and acute mountain sickness which share phenotypical similarities with migraine. Epidemiological data indicate an increased prevalence of migraine with and without aura in high-altitude populations. Experimental studies have further shown that hypoxia can induce migraine attacks. This review summarizes evidence linking hypoxia to migraine, delves into potential pathophysiological mechanisms and highlights research gaps.

AB - Migraine, a common neurological disorder, impacts over a billion individuals globally. Its complex aetiology involves various signalling cascades. Hypoxia causes headaches such as high-altitude headache and acute mountain sickness which share phenotypical similarities with migraine. Epidemiological data indicate an increased prevalence of migraine with and without aura in high-altitude populations. Experimental studies have further shown that hypoxia can induce migraine attacks. This review summarizes evidence linking hypoxia to migraine, delves into potential pathophysiological mechanisms and highlights research gaps.

KW - Altitude Sickness/physiopathology

KW - Animals

KW - Humans

KW - Hypoxia/physiopathology

KW - Migraine Disorders/physiopathology

KW - Migraine with Aura/physiopathology

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DO - 10.1113/JP284553

M3 - Review

C2 - 38279931

SN - 0022-3751

VL - 602

SP - 5515

EP - 5522

JO - The Journal of physiology

JF - The Journal of physiology

IS - 21

ER -

Migraine headache and aura induced by hypoxia

Abstract

Keywords

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