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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Migraine and cluster headache - the common link

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    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Cilostazol induced migraine does not respond to sumatriptan in a double blind trial

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  3. Fremanezumab blocks CGRP induced dilatation in human cerebral, middle meningeal and abdominal arteries

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  1. PACAP27 induces migraine-like attacks in migraine patients

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  2. Effect of pituitary adenylate cyclase-activating polypeptide-27 on cerebral hemodynamics in healthy volunteers: A 3T MRI study

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Calcitonin gene-related peptide - beyond migraine prophylaxis

    Research output: Contribution to journalComment/debateResearchpeer-review

  4. Post-traumatic headache: epidemiology and pathophysiological insights

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  • Anne Luise Vollesen
  • Silvia Benemei
  • Francesca Cortese
  • Alejandro Labastida-Ramírez
  • Francesca Marchese
  • Lanfranco Pellesi
  • Michele Romoli
  • Messoud Ashina
  • Christian Lampl
  • School of Advanced Studies of the European Headache Federation (EHF-SAS)
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Although clinically distinguishable, migraine and cluster headache share prominent features such as unilateral pain, common pharmacological triggers such glyceryl trinitrate, histamine, calcitonin gene-related peptide (CGRP) and response to triptans and neuromodulation. Recent data also suggest efficacy of anti CGRP monoclonal antibodies in both migraine and cluster headache. While exact mechanisms behind both disorders remain to be fully understood, the trigeminovascular system represents one possible common pathophysiological pathway and network of both disorders. Here, we review past and current literature shedding light on similarities and differences in phenotype, heritability, pathophysiology, imaging findings and treatment options of migraine and cluster headache. A continued focus on their shared pathophysiological pathways may be important in paving future treatment avenues that could benefit both migraine and cluster headache patients.

Original languageEnglish
JournalJournal of Headache and Pain
Volume19
Issue number1
Pages (from-to)89
ISSN1129-2369
DOIs
Publication statusPublished - 2018

ID: 55588052