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microRNA-9 targets the long non-coding RNA MALAT1 for degradation in the nucleus

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  • Eleonora Leucci
  • Francesca Patella
  • Johannes Waage
  • Kim Holmstrøm
  • Morten Lindow
  • Bo Porse
  • Markus Sakari Kauppinen
  • Anders H. Lund
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microRNAs regulate the expression of over 60% of protein coding genes by targeting their mRNAs to AGO2-containing complexes in the cytoplasm and promoting their translational inhibition and/or degradation. There is little evidence so far for microRNA-mediated regulation of other classes of non-coding RNAs. Here we report that microRNA-9 (miR-9) regulates the expression of the Metastasis Associated Lung Adenocarcinoma Transcript 1 (MALAT-1), one of the most abundant and conserved long non-coding RNAs. Intriguingly, we find that miR-9 targets AGO2-mediated regulation of MALAT1 in the nucleus. Our findings reveal a novel direct regulatory link between two important classes of non-coding RNAs, miRs and lncRNAs, and advance our understanding of microRNA functions.
Original languageEnglish
JournalScientific Reports
Volume3
Pages (from-to)2535
ISSN2045-2322
DOIs
Publication statusPublished - 29 Aug 2013

ID: 39009416