Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

microRNA-9 targets the long non-coding RNA MALAT1 for degradation in the nucleus

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Body mass index in young men and risk of inflammatory bowel disease through adult life: A population-based Danish cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Leukocyte telomere length is associated with elevated plasma glucose and HbA1c in young healthy men independent of birth weight

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Multidimensional diffusion MRI with spectrally modulated gradients reveals unprecedented microstructural detail

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. The splicing factor RBM25 controls MYC activity in acute myeloid leukemia

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Genetic, Clinical, and Environmental Factors Associated With Persistent Atopic Dermatitis in Childhood

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Leukemogenic nucleophosmin mutation disrupts the transcription factor hub regulating granulo-monocytic fates

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Consortium-based genome-wide meta-analysis for childhood dental caries traits

    Research output: Contribution to journalJournal articleResearchpeer-review

  • Eleonora Leucci
  • Francesca Patella
  • Johannes Waage
  • Kim Holmstrøm
  • Morten Lindow
  • Bo Porse
  • Markus Sakari Kauppinen
  • Anders H. Lund
View graph of relations
microRNAs regulate the expression of over 60% of protein coding genes by targeting their mRNAs to AGO2-containing complexes in the cytoplasm and promoting their translational inhibition and/or degradation. There is little evidence so far for microRNA-mediated regulation of other classes of non-coding RNAs. Here we report that microRNA-9 (miR-9) regulates the expression of the Metastasis Associated Lung Adenocarcinoma Transcript 1 (MALAT-1), one of the most abundant and conserved long non-coding RNAs. Intriguingly, we find that miR-9 targets AGO2-mediated regulation of MALAT1 in the nucleus. Our findings reveal a novel direct regulatory link between two important classes of non-coding RNAs, miRs and lncRNAs, and advance our understanding of microRNA functions.
Original languageEnglish
JournalScientific Reports
Volume3
Pages (from-to)2535
ISSN2045-2322
DOIs
Publication statusPublished - 29 Aug 2013

ID: 39009416