MicroRNA-regulated non-viral vectors with improved tumor specificity in an orthotopic rat model of hepatocellular carcinoma

J A Ronald; R Katzenberg; C H Nielsen; H J Jae; L V Hofmann; S S Gambhir

doi:10.1038/gt.2013.24

MicroRNA-regulated non-viral vectors with improved tumor specificity in an orthotopic rat model of hepatocellular carcinoma

J A Ronald, R Katzenberg, C H Nielsen, H J Jae, L V Hofmann, S S Gambhir

Department of Clinical Physiology and Nuclear Medicine

7 Citations (Scopus)

Abstract

In hepatocellular carcinoma (HCC), tumor specificity of gene therapy is of utmost importance to preserve liver function. MicroRNAs (miRNAs) are powerful negative regulators of gene expression and many are downregulated in human HCC. We identified seven miRNAs that are also downregulated in tumors in a rat hepatoma model (P

Original language	English
Journal	Gene Therapy
Volume	20
Issue number	10
Pages (from-to)	1006-13
Number of pages	8
ISSN	0969-7128
DOIs	https://doi.org/10.1038/gt.2013.24
Publication status	Published - Oct 2013

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10.1038/gt.2013.24

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title = "MicroRNA-regulated non-viral vectors with improved tumor specificity in an orthotopic rat model of hepatocellular carcinoma",

abstract = "In hepatocellular carcinoma (HCC), tumor specificity of gene therapy is of utmost importance to preserve liver function. MicroRNAs (miRNAs) are powerful negative regulators of gene expression and many are downregulated in human HCC. We identified seven miRNAs that are also downregulated in tumors in a rat hepatoma model (P",

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AU - Katzenberg, R

AU - Nielsen, C H

AU - Jae, H J

AU - Hofmann, L V

AU - Gambhir, S S

PY - 2013/10

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AB - In hepatocellular carcinoma (HCC), tumor specificity of gene therapy is of utmost importance to preserve liver function. MicroRNAs (miRNAs) are powerful negative regulators of gene expression and many are downregulated in human HCC. We identified seven miRNAs that are also downregulated in tumors in a rat hepatoma model (P

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MicroRNA-regulated non-viral vectors with improved tumor specificity in an orthotopic rat model of hepatocellular carcinoma

Abstract

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