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The Capital Region of Denmark - a part of Copenhagen University Hospital
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MicroRNA profiling in ocular adnexal lymphoma: a role for MYC and NFKB1 mediated dysregulation of microRNA expression in aggressive disease

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  1. Clinical Characterization of 66 Patients With Congenital Retinal Disease Due to the Deep-Intronic c.2991+1655A>G Mutation in CEP290

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  2. Endothelial Protein C-Targeting Liposomes Show Enhanced Uptake and Improved Therapeutic Efficacy in Human Retinal Endothelial Cells

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  3. Effects of Prenatal Alcohol Exposure on the Visual System of Monkeys Measured at Different Stages of Development

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  4. Loss of Melanopsin-Expressing Retinal Ganglion Cells in Patients With Diabetic Retinopathy

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  1. Epigenetic therapy in hematological cancers

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  2. Inverted papilloma of the conjunctiva

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  3. KRAS mutations in the parental tumour accelerate in vitro growth of tumoroids established from colorectal adenocarcinoma

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  4. Periocular necrotizing soft tissue infection in Greater Copenhagen

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  5. A presentation of culture-positive corneal donors and the effect on clinical outcomes

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Ocular adnexal lymphoma (i.e., lymphoma with involvement of the orbit, eyelids, conjunctiva, lacrimal gland, and lacrimal sac), although rare, is common among malignant tumors involving the ocular adnexal region. The main subtypes are low-grade extranodal marginal zone lymphoma (EMZL) and aggressive diffuse large B-cell lymphoma (DLBCL). In rare cases, low-grade EMZL are reported to transform to DLBCL. It is unclear, however, which genetic events distinguish low-grade disease from aggressive, potentially fatal disease.
Original languageEnglish
JournalInvestigative ophthalmology & visual science
Volume54
Issue number8
Pages (from-to)5169-75
Number of pages7
ISSN0146-0404
DOIs
Publication statusPublished - Aug 2013

    Research areas

  • Adult, Aged, Aged, 80 and over, Conjunctival Neoplasms, Eye Neoplasms, Female, Follow-Up Studies, Gene Expression Regulation, Neoplastic, Humans, Lacrimal Apparatus, Lymphoma, Large B-Cell, Diffuse, Male, MicroRNAs, Middle Aged, NF-kappa B p50 Subunit, Orbital Neoplasms, Protein Array Analysis, Proto-Oncogene Proteins c-myc, RNA, Neoplasm, Real-Time Polymerase Chain Reaction

ID: 41370706