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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Microcirculatory Function in Nonhypertrophic and Hypertrophic Myocardium in Patients With Aortic Valve Stenosis

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DOI

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  3. Activation of Citizen Responders to Out-of-Hospital Cardiac Arrest During the COVID-19 Outbreak in Denmark 2020

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  1. Center Valve Preference and Outcomes of Transcatheter Aortic Valve Replacement: Insights From the AMTRAC Registry

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  2. Early Coronary Atherosclerosis in Women With Previous Preeclampsia

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  3. Does Subclinical Leaflet Thrombosis Impact the Durability of Bioprosthetic Aortic Valves?

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  4. Transcatheter Mitral Valve Repair or Replacement: Competitive or Complementary?

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Background Left ventricular hypertrophy (LVH) has often been supposed to be associated with abnormal myocardial blood flow and resistance. The aim of this study was to evaluate and quantify the physiological and pathological changes in myocardial blood flow and microcirculatory resistance in patients with and without LVH attributable to severe aortic stenosis. Methods and Results Absolute coronary blood flow and microvascular resistance were measured using a novel technique with continuous thermodilution and infusion of saline. In addition, myocardial mass was assessed with cardiac magnetic resonance imaging. Fifty-three patients with aortic valve stenosis were enrolled in the study. In 32 patients with LVH, hyperemic blood flow per gram of tissue was significantly decreased compared with 21 patients without LVH (1.26±0.48 versus 1.66±0.65 mL·min-1·g-1; P=0.018), whereas minimal resistance indexed for left ventricular mass was significantly increased in patients with LVH (63 [47-82] versus 43 [35-63] Wood Units·kg; P=0.014). Conclusions Patients with LVH attributable to severe aortic stenosis had lower hyperemic blood flow per gram of myocardium and higher minimal myocardial resistance compared with patients without LVH.

Original languageEnglish
Article numbere025381
JournalJournal of the American Heart Association
Volume11
Issue number9
Pages (from-to)1-11
Number of pages11
ISSN2047-9980
DOIs
Publication statusPublished - 3 May 2022

    Research areas

  • Aortic Valve Stenosis/complications, Hemodynamics, Humans, Hypertrophy, Left Ventricular/pathology, Microcirculation, Myocardium/pathology, aortic stenosis, coronary flow, left ventricular hypertrophy, cardiac magnetic resonance imaging, microvascular function, thermodilution

ID: 77893797