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Methods of investigation for cardiac autonomic dysfunction in human research studies

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  • Luciano Bernardi
  • Vincenza Spallone
  • Martin Stevens
  • Jannik Hilsted
  • Simona Frontoni
  • Rodica Pop-Busui
  • Dan Ziegler
  • Peter Kempler
  • Roy Freeman
  • Phillip Low
  • Solomon Tesfaye
  • Paul Valensi
  • on behalf of the Toronto Consensus Panel on Diabetic Neuropathy*
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This consensus document provides evidence-based guidelines regarding the evaluation of diabetic cardiovascular autonomic neuropathy (CAN) for human research studies as a result of the work of the CAN Subcommittee of the Toronto Diabetic Neuropathy Expert Group. The CAN subcommittee critically reviewed the limitations and strengths of the available diagnostic approaches for CAN and the need for developing new tests for autonomic function. It was concluded that the most sensitive and specific approaches currently available to evaluate CAN in clinical research are: 1) heart rate variability, 2) baroreflex sensitivity, 3) muscle sympathetic nerve activity, 4) plasma catecholamines, and 5) heart sympathetic imaging. It was also recommended that efforts should be undertaken to develop new non-invasive and safe CAN tests to be used in clinical research, with a higher sensitivity and specificity, for studying the pathophysiology of CAN and new therapeutic approaches. Copyright © 2011 John Wiley & Sons, Ltd.
Original languageEnglish
JournalDiabetes - Metabolism: Research and Reviews (Print Edition)
Volume27
Issue number7
Pages (from-to)654-664
ISSN1520-7552
DOIs
Publication statusPublished - 2011

ID: 34834051