Metformin treatment is associated with a low risk of mortality in diabetic patients with heart failure: a retrospective nationwide cohort study

Charlotte Andersson; Jonas Bjerring Olesen; P R Hansen; P Weeke; Mette Lykke Norgaard; C H Jørgensen; T Lange; S Z Abildstrøm; T K Schramm; Allan Vaag; L Køber; C Torp-Pedersen; G H Gislason

doi:10.1007/s00125-010-1906-6

Metformin treatment is associated with a low risk of mortality in diabetic patients with heart failure: a retrospective nationwide cohort study

Charlotte Andersson, Jonas Bjerring Olesen, P R Hansen, P Weeke, Mette Lykke Norgaard, C H Jørgensen, T Lange, S Z Abildstrøm, T K Schramm, Allan Vaag, L Køber, C Torp-Pedersen, G H Gislason

Department of Medicine, Glostrup

142 Citations (Scopus)

Abstract

The safety of metformin in heart failure has been questioned because of a perceived risk of life-threatening lactic acidosis, though recent studies have not supported this concern. We investigated the risk of all-cause mortality associated with individual glucose-lowering treatment regimens used in current clinical practice in Denmark.

Original language	English
Journal	Diabetologia
Volume	53
Issue number	12
Pages (from-to)	2546-53
Number of pages	8
ISSN	0012-186X
DOIs	https://doi.org/10.1007/s00125-010-1906-6
Publication status	Published - 1 Dec 2010

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Andersson, C., Olesen, J. B., Hansen, P. R., Weeke, P., Norgaard, M. L., Jørgensen, C. H., Lange, T., Abildstrøm, S. Z., Schramm, T. K., Vaag, A., Køber, L., Torp-Pedersen, C., & Gislason, G. H. (2010). Metformin treatment is associated with a low risk of mortality in diabetic patients with heart failure: a retrospective nationwide cohort study. Diabetologia, 53(12), 2546-53. https://doi.org/10.1007/s00125-010-1906-6

Andersson, C , Olesen, JB , Hansen, PR , Weeke, P , Norgaard, ML, Jørgensen, CH, Lange, T, Abildstrøm, SZ, Schramm, TK , Vaag, A , Køber, L , Torp-Pedersen, C & Gislason, GH 2010, 'Metformin treatment is associated with a low risk of mortality in diabetic patients with heart failure: a retrospective nationwide cohort study', Diabetologia, vol. 53, no. 12, pp. 2546-53. https://doi.org/10.1007/s00125-010-1906-6

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author = "Charlotte Andersson and Olesen, \{Jonas Bjerring\} and Hansen, \{P R\} and P Weeke and Norgaard, \{Mette Lykke\} and J{\o}rgensen, \{C H\} and T Lange and Abildstr{\o}m, \{S Z\} and Schramm, \{T K\} and Allan Vaag and L K{\o}ber and C Torp-Pedersen and Gislason, \{G H\}",

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AU - Weeke, P

AU - Norgaard, Mette Lykke

AU - Jørgensen, C H

AU - Lange, T

AU - Abildstrøm, S Z

AU - Schramm, T K

AU - Vaag, Allan

AU - Køber, L

AU - Torp-Pedersen, C

AU - Gislason, G H

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AB - The safety of metformin in heart failure has been questioned because of a perceived risk of life-threatening lactic acidosis, though recent studies have not supported this concern. We investigated the risk of all-cause mortality associated with individual glucose-lowering treatment regimens used in current clinical practice in Denmark.

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Metformin treatment is associated with a low risk of mortality in diabetic patients with heart failure: a retrospective nationwide cohort study

Abstract

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