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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Metformin og kirurgi i generel anæstesi

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  1. The current epidemic of HPV-associated oropharyngeal cancer: An 18-year Danish population-based study with 2,169 patients

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  2. Association between head and neck cancer and sexually transmitted diseases: a Danish nationwide, case-control study

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  3. Enhanced Recovery After Head and Neck Cancer Reconstruction With a Free Flap-What Is Next?

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  4. Microvascular reconstruction in head and neck cancer - basis for the development of an enhanced recovery protocol

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  5. Incidence and survival of hypopharyngeal cancer: a Danish Nation-Wide Study from 1980 to 2014

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Danish national guidelines recommend discontinuation of metformin 48 h prior to general anaesthesia due to the presumed increased risk of lactic acidosis. By reviewing recent studies concerning the risk of metformin-associated lactic acidosis it is found, that studies indicate, that metformin does not increase the risk of lactic acidosis. However, comorbidities such as cardiovascular insufficiency, sepsis, dehydration and impaired kidney function are risk factors. New guidelines propose discontinuation of metformin on the day of surgery. Patients with Type 2 diabetes and comorbidities should have the levels of arterial pH and lactate monitored.

Translated title of the contributionMetformin and surgery before general anaesthesia
Original languageDanish
JournalUgeskrift for Laeger
Volume180
Issue number51
ISSN0041-5782
Publication statusPublished - 17 Dec 2018

ID: 56706488