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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Metabolomic Biomarkers in the Progression to Type 1 Diabetes

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  1. Lipidomic Abnormalities During the Pathogenesis of Type 1 Diabetes: a Quantitative Review

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  2. Diabetes Management During Breastfeeding in Women with Type 1 Diabetes

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  3. Current Therapies That Modify Glucagon Secretion: What Is the Therapeutic Effect of Such Modifications?

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  4. Can Cardiovascular Epidemiology and Clinical Trials Close the Risk Management Gap Between Diabetes and Prediabetes?

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  1. Lipidomics of human adipose tissue reveals diversity between body areas

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  2. Decreased markers of bone turnover in children and adolescents with type 1 diabetes

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  3. Unaffected bone mineral density in Danish children and adolescents with type 1 diabetes

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  4. Bone turnover markers during the remission phase in children and adolescents with type 1 diabetes

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  5. Linking glycemic dysregulation in diabetes to symptoms, comorbidities, and genetics through EHR data mining

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Metabolomics is the snapshot of all detectable metabolites and lipids in biological materials and has potential in reflecting genetic and environmental factors contributing to the development of complex diseases, such as type 1 diabetes. The progression to seroconversion to development of type 1 diabetes has been studied using this technique, although in relatively small cohorts and at limited time points. Overall, three observations have been consistently reported; phospholipids at birth are lower in children developing type 1 diabetes early in childhood, methionine levels are lower in children at seroconversion, and triglycerides are increased at seroconversion and associated to microbiome diversity, indicating an association between the metabolome and microbiome in type 1 diabetes progression.

Original languageEnglish
Article number127
JournalCurrent Diabetes Reports
Volume16
Issue number12
Number of pages5
ISSN1534-4827
DOIs
Publication statusPublished - Dec 2016

    Research areas

  • Review, Journal Article

ID: 49915786