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Metabolic responses to hypoglycemia in juvenile diabetics

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@article{2847fd2155354f61904f52c229a03850,
title = "Metabolic responses to hypoglycemia in juvenile diabetics",
abstract = "Glucagon and metabolic responses to insulin-induced hypoglycemia were studied in seven juvenile diabetics, age 31 +/- 2 years (mean and S.E.M.), duration of diabetes 17 +/- 3 years, with diabetic autonomic neuropathy (decreased beat-to-beat variation in heart rate during hyperventilation and/or orthostatic hypotension) and in seven control patients of similar age and duration of diabetes with out neuropathy. Before the hypoglycaemic episode, normoglycemia had been maintained for at least 10 hours. Following hypoglycemia, a slight but significant and similar increase in plasma glucagon was found in both patient groups. Metabolic responses to hypoglycemia were also similar in the two patient groups. In conclusion, diabetic autonomic neuropathy has no effect on glucagon and metabolic responses to hypoglycemia in juvenile, insulin-treated diabetics.",
keywords = "Adult, Autonomic Nervous System Diseases, Blood Glucose, Diabetes Mellitus, Type 1, Diabetic Neuropathies, Fatty Acids, Nonesterified, Glucagon, Humans, Hypoglycemia, Male",
author = "J Hilsted and S Madsbad and T Krarup and Heding, {L G} and L Sestoft",
year = "1980",
language = "English",
volume = "639",
pages = "25--8",
journal = "Acta Medica Scandinavica, Supplement",
issn = "0365-463X",
publisher = "Almgvist & Wiksells",

}

RIS

TY - JOUR

T1 - Metabolic responses to hypoglycemia in juvenile diabetics

AU - Hilsted, J

AU - Madsbad, S

AU - Krarup, T

AU - Heding, L G

AU - Sestoft, L

PY - 1980

Y1 - 1980

N2 - Glucagon and metabolic responses to insulin-induced hypoglycemia were studied in seven juvenile diabetics, age 31 +/- 2 years (mean and S.E.M.), duration of diabetes 17 +/- 3 years, with diabetic autonomic neuropathy (decreased beat-to-beat variation in heart rate during hyperventilation and/or orthostatic hypotension) and in seven control patients of similar age and duration of diabetes with out neuropathy. Before the hypoglycaemic episode, normoglycemia had been maintained for at least 10 hours. Following hypoglycemia, a slight but significant and similar increase in plasma glucagon was found in both patient groups. Metabolic responses to hypoglycemia were also similar in the two patient groups. In conclusion, diabetic autonomic neuropathy has no effect on glucagon and metabolic responses to hypoglycemia in juvenile, insulin-treated diabetics.

AB - Glucagon and metabolic responses to insulin-induced hypoglycemia were studied in seven juvenile diabetics, age 31 +/- 2 years (mean and S.E.M.), duration of diabetes 17 +/- 3 years, with diabetic autonomic neuropathy (decreased beat-to-beat variation in heart rate during hyperventilation and/or orthostatic hypotension) and in seven control patients of similar age and duration of diabetes with out neuropathy. Before the hypoglycaemic episode, normoglycemia had been maintained for at least 10 hours. Following hypoglycemia, a slight but significant and similar increase in plasma glucagon was found in both patient groups. Metabolic responses to hypoglycemia were also similar in the two patient groups. In conclusion, diabetic autonomic neuropathy has no effect on glucagon and metabolic responses to hypoglycemia in juvenile, insulin-treated diabetics.

KW - Adult

KW - Autonomic Nervous System Diseases

KW - Blood Glucose

KW - Diabetes Mellitus, Type 1

KW - Diabetic Neuropathies

KW - Fatty Acids, Nonesterified

KW - Glucagon

KW - Humans

KW - Hypoglycemia

KW - Male

M3 - Journal article

VL - 639

SP - 25

EP - 28

JO - Acta Medica Scandinavica, Supplement

JF - Acta Medica Scandinavica, Supplement

SN - 0365-463X

ER -

ID: 40162706