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Metabolic Health in Severely Obese Subjects: A Descriptive Study

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@article{2869d771fb5a440ba080f18cf65ed244,
title = "Metabolic Health in Severely Obese Subjects: A Descriptive Study",
abstract = "BACKGROUND: The prevalence of metabolically healthy obese (MHO) subjects among morbidly obese subjects is poorly described.AIM: To describe the prevalence of metabolically healthy subjects in a group of morbidly obese referred for bariatric surgery.METHODS: Descriptive cross-sectional study, 1209 subjects (825 women/384 men) mean body mass index (BMI) of 45.6 (range: 35-72.6) kg/m2 and mean age of 42.9 (range: 18-72) years were included. Metabolically unhealthy obese subjects had at least two metabolic risk factors: systolic blood pressure >130 mmHg or diastolic blood pressure >85 mmHg or use of antihypertensive medication, diagnosed diabetes with a HbA1c >6.5{\%} (>48 mmol/mol) or use of antidiabetic medication, high plasma triglycerides or low plasma high-density lipoprotein, or use of lipid-lowering medication. MHO subjects had one or no metabolic risk factors.RESULTS: Thirty-four percent (413/1209) were characterized as MHO subjects. The MHO stage was characterized by female sex, younger age, and lower neck and waist circumferences. The odds ratio of metabolic unhealthy was 1.12 (1.07-1.17, P < 0.001) and 1.02 (1.01-1.04, P < 0002) for every 1 cm increase in neck and waist circumferences, respectively, and 0.94 (0.91-0.97, P < 0.001) for every 1 U increase in BMI and 1.04 (1.03-1.05, P < 0.001) for every 1 year increase in age.CONCLUSIONS: Among severely obese subjects, 34{\%} were classified as having a metabolically healthy state, which was more likely to occur in females, younger individuals and was associated with a lower neck and waist circumferences, younger age, and higher BMI. Whether a group of MHO subjects will remain healthy lifelong is unknown.",
keywords = "BMI, insulin resistance, metabolically healthy obese, metabolically unhealthy obese, neck circumference",
author = "Dorte Worm and Sten Madsbad and Hansen, {Dorte L}",
year = "2019",
month = "3",
day = "1",
doi = "10.1089/met.2018.0083",
language = "English",
volume = "17",
pages = "115--119",
journal = "Metabolic Syndrome and Related Disorders",
issn = "1540-4196",
publisher = "Mary Ann/Liebert, Inc. Publishers",
number = "2",

}

RIS

TY - JOUR

T1 - Metabolic Health in Severely Obese Subjects

T2 - A Descriptive Study

AU - Worm, Dorte

AU - Madsbad, Sten

AU - Hansen, Dorte L

PY - 2019/3/1

Y1 - 2019/3/1

N2 - BACKGROUND: The prevalence of metabolically healthy obese (MHO) subjects among morbidly obese subjects is poorly described.AIM: To describe the prevalence of metabolically healthy subjects in a group of morbidly obese referred for bariatric surgery.METHODS: Descriptive cross-sectional study, 1209 subjects (825 women/384 men) mean body mass index (BMI) of 45.6 (range: 35-72.6) kg/m2 and mean age of 42.9 (range: 18-72) years were included. Metabolically unhealthy obese subjects had at least two metabolic risk factors: systolic blood pressure >130 mmHg or diastolic blood pressure >85 mmHg or use of antihypertensive medication, diagnosed diabetes with a HbA1c >6.5% (>48 mmol/mol) or use of antidiabetic medication, high plasma triglycerides or low plasma high-density lipoprotein, or use of lipid-lowering medication. MHO subjects had one or no metabolic risk factors.RESULTS: Thirty-four percent (413/1209) were characterized as MHO subjects. The MHO stage was characterized by female sex, younger age, and lower neck and waist circumferences. The odds ratio of metabolic unhealthy was 1.12 (1.07-1.17, P < 0.001) and 1.02 (1.01-1.04, P < 0002) for every 1 cm increase in neck and waist circumferences, respectively, and 0.94 (0.91-0.97, P < 0.001) for every 1 U increase in BMI and 1.04 (1.03-1.05, P < 0.001) for every 1 year increase in age.CONCLUSIONS: Among severely obese subjects, 34% were classified as having a metabolically healthy state, which was more likely to occur in females, younger individuals and was associated with a lower neck and waist circumferences, younger age, and higher BMI. Whether a group of MHO subjects will remain healthy lifelong is unknown.

AB - BACKGROUND: The prevalence of metabolically healthy obese (MHO) subjects among morbidly obese subjects is poorly described.AIM: To describe the prevalence of metabolically healthy subjects in a group of morbidly obese referred for bariatric surgery.METHODS: Descriptive cross-sectional study, 1209 subjects (825 women/384 men) mean body mass index (BMI) of 45.6 (range: 35-72.6) kg/m2 and mean age of 42.9 (range: 18-72) years were included. Metabolically unhealthy obese subjects had at least two metabolic risk factors: systolic blood pressure >130 mmHg or diastolic blood pressure >85 mmHg or use of antihypertensive medication, diagnosed diabetes with a HbA1c >6.5% (>48 mmol/mol) or use of antidiabetic medication, high plasma triglycerides or low plasma high-density lipoprotein, or use of lipid-lowering medication. MHO subjects had one or no metabolic risk factors.RESULTS: Thirty-four percent (413/1209) were characterized as MHO subjects. The MHO stage was characterized by female sex, younger age, and lower neck and waist circumferences. The odds ratio of metabolic unhealthy was 1.12 (1.07-1.17, P < 0.001) and 1.02 (1.01-1.04, P < 0002) for every 1 cm increase in neck and waist circumferences, respectively, and 0.94 (0.91-0.97, P < 0.001) for every 1 U increase in BMI and 1.04 (1.03-1.05, P < 0.001) for every 1 year increase in age.CONCLUSIONS: Among severely obese subjects, 34% were classified as having a metabolically healthy state, which was more likely to occur in females, younger individuals and was associated with a lower neck and waist circumferences, younger age, and higher BMI. Whether a group of MHO subjects will remain healthy lifelong is unknown.

KW - BMI

KW - insulin resistance

KW - metabolically healthy obese

KW - metabolically unhealthy obese

KW - neck circumference

UR - http://www.scopus.com/inward/record.url?scp=85062412810&partnerID=8YFLogxK

U2 - 10.1089/met.2018.0083

DO - 10.1089/met.2018.0083

M3 - Journal article

VL - 17

SP - 115

EP - 119

JO - Metabolic Syndrome and Related Disorders

JF - Metabolic Syndrome and Related Disorders

SN - 1540-4196

IS - 2

ER -

ID: 56275190