Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Metabolic effects of short-term GLP-1 treatment in insulin resistant heart failure patients

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Risk Factors for Premature Death in Diabetes Patients who Undergo Amputations below Ankle Level

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. The Diabetic Foot in a Multidisciplinary Team Setting. Number of Amputations below Ankle Level and Mortality

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Insulin-like growth factor I and anthropometric parameters in a Danish population

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Thyrocyte-interleukin-1 interactions

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Circulating nociceptin and CGRP in medication-overuse headache

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Part II: Biochemical changes after pituitary adenylate cyclase-activating polypeptide-38 infusion in migraine patients

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Effect of paracentesis on metabolic activity in patients with advanced cirrhosis and ascites

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Hemodynamic responses to mental stress during salt loading

    Research output: Contribution to journalJournal articleResearchpeer-review

  • R Nielsen
  • Henrik Wiggers
  • Mads Halbirk
  • Hans Erik Bøtker
  • Jens Juul Holst
  • Ole Schmitz
  • E Frandsen
  • S Nielsen
  • N Møller
  • Helene Nørrelund
View graph of relations
We studied the metabolic effects of 48-h GLP-1 treatment in insulin resistant heart failure patients.In a randomized placebo-controlled double-blinded cross-over study, 11 non-diabetic HF patients with IHD received 48-h GLP-1 and placebo-infusion. We applied OGTT, hyperinsulinemic clamp, indirect calorimetry, forearm, and tracer methods.7 insulin resistant HF (EF 28%±2) patients completed the protocol. GLP-1 decreased plasma glucose levels (p=0.048) and improved glucose tolerance. 4 patients had hypoglycemic events during GLP-1 vs. none during placebo. GLP-1 treatment tended to increase whole body protein turnover (p=0.08) but did not cause muscle wasting. No significant changes in circulating levels of insulin, glucagon, free fatty acids or insulin sensitivity were detected.GLP-1 treatment decreased glucose levels and increased glucose tolerance in insulin resistant HF patients with IHD. Hypoglycemia was common and may limit the use of GLP-1 in these patients. Insulin sensitivity, lipid-, and protein metabolism remained unchanged.Data were collected at the examinational laboratories of Department of Endocrinology and Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark.
Original languageEnglish
JournalExperimental and Clinical Endocrinology and Diabetes
Volume120
Issue number5
Pages (from-to)266-72
Number of pages7
ISSN0947-7349
DOIs
Publication statusPublished - 2012

    Research areas

  • Blood Glucose, Calorimetry, Indirect, Cross-Over Studies, Double-Blind Method, Drug Administration Schedule, Fatty Acids, Nonesterified, Glucagon, Glucagon-Like Peptide 1, Glucose Clamp Technique, Glucose Tolerance Test, Heart Failure, Humans, Insulin, Insulin Resistance, Male, Middle Aged

ID: 36833023