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Metabolic effects of 1-week binge drinking and fast food intake during Roskilde Festival in young healthy male adults

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@article{94239d2e3c7a4ec88a94e019414291d2,
title = "Metabolic effects of 1-week binge drinking and fast food intake during Roskilde Festival in young healthy male adults",
abstract = "Aims/hypothesis: Metabolic effects of intermittent unhealthy lifestyle in young adults are poorly studied. We investigated the gluco-metabolic and hepatic effects of participation in Roskilde Festival (1 week of binge drinking and junk food consumption) in young, healthy males.Methods: Fourteen festival participants (FP) were studied before, during and after 1 week's participation in Roskilde Festival. Fourteen matched controls (CTRL) who did not participate in Roskilde Festival or change their lifestyle in other ways were investigated along a similar timeline.Results: The FP group consumed more alcohol compared to their standard living conditions (2.0 ± 3.9 vs 16.3 ± 8.3 units/day, P < 0.001). CTRLs did not change their alcohol consumption. AUC for glucose during OGTT did not change in either group. C-peptide responses increased in the FP group (206 ± 24 vs 236 ± 17 min × nmol/L, P = 0.052) and the Matsuda index of insulin sensitivity decreased (6.2 ± 2.4 vs 4.7 ± 1.4, P = 0.054). AUC for glucagon during oral glucose tolerance test (OGTT) increased in the FP group (1037 ± 90 vs 1562 ± 195 min × pmol/L, P = 0.003) together with fasting fibroblast growth factor 21 (FGF21) (62 ± 30 vs 132 ± 72 pmol/L, P < 0.001), growth differentiation factor 15 (GDF5) (276 ± 78 vs 330 ± 83 pg/mL, P = 0.009) and aspartate aminotransferase (AST) levels (37.6 ± 6.8 vs 42.4 ± 11 U/L, P = 0.043). Four participants (29%) developed ultrasound-detectable steatosis and a mean strain elastography-assessed liver stiffness increased (P = 0.026) in the FP group.Conclusions/Interpretation: Participation in Roskilde Festival did not affect oral glucose tolerance but was associated with a reduction in insulin sensitivity, increases in glucagon, FGF21, GDF15 and AST and lead to increased liver stiffness and, in 29% of the participants, ultrasound-detectable hepatic steatosis.",
keywords = "Adult, Aspartate Aminotransferases/metabolism, Binge Drinking/metabolism, Blood Glucose/metabolism, C-Peptide/metabolism, C-Reactive Protein/metabolism, Denmark, Diet, Elasticity Imaging Techniques, Fast Foods, Fatty Liver/diagnostic imaging, Fibroblast Growth Factors/metabolism, Glucagon/metabolism, Glucose Tolerance Test, Growth Differentiation Factor 15/metabolism, Holidays, Humans, Insulin Resistance, Liver/diagnostic imaging, Male, Young Adult",
author = "Mia Demant and Suppli, {Malte P} and Signe Foghsgaard and Lise Gether and Gr{\o}ndahl, {Magnus F G} and Dalsgaard, {Niels B} and Bergmann, {Sigrid S} and Lanng, {Amalie R} and Gasbjerg, {L{\ae}rke S} and Martin Thomasen and Bagger, {Jonatan I} and Charlotte Strandberg and K{\o}nig, {Merete J} and Henning Gr{\o}nb{\ae}k and Ulrik Becker and {Wewer Albrechtsen}, {Nicolai J} and Holst, {Jens J} and Joachim Knop and Gillum, {Matthew P} and Tina Vilsb{\o}ll and Knop, {Filip K}",
year = "2021",
month = may,
day = "21",
doi = "10.1530/EJE-21-0122",
language = "English",
volume = "185",
pages = "23--32",
journal = "European Journal of Endocrinology",
issn = "0804-4643",
publisher = "BioScientifica Ltd.",
number = "1",

}

RIS

TY - JOUR

T1 - Metabolic effects of 1-week binge drinking and fast food intake during Roskilde Festival in young healthy male adults

AU - Demant, Mia

AU - Suppli, Malte P

AU - Foghsgaard, Signe

AU - Gether, Lise

AU - Grøndahl, Magnus F G

AU - Dalsgaard, Niels B

AU - Bergmann, Sigrid S

AU - Lanng, Amalie R

AU - Gasbjerg, Lærke S

AU - Thomasen, Martin

AU - Bagger, Jonatan I

AU - Strandberg, Charlotte

AU - Kønig, Merete J

AU - Grønbæk, Henning

AU - Becker, Ulrik

AU - Wewer Albrechtsen, Nicolai J

AU - Holst, Jens J

AU - Knop, Joachim

AU - Gillum, Matthew P

AU - Vilsbøll, Tina

AU - Knop, Filip K

PY - 2021/5/21

Y1 - 2021/5/21

N2 - Aims/hypothesis: Metabolic effects of intermittent unhealthy lifestyle in young adults are poorly studied. We investigated the gluco-metabolic and hepatic effects of participation in Roskilde Festival (1 week of binge drinking and junk food consumption) in young, healthy males.Methods: Fourteen festival participants (FP) were studied before, during and after 1 week's participation in Roskilde Festival. Fourteen matched controls (CTRL) who did not participate in Roskilde Festival or change their lifestyle in other ways were investigated along a similar timeline.Results: The FP group consumed more alcohol compared to their standard living conditions (2.0 ± 3.9 vs 16.3 ± 8.3 units/day, P < 0.001). CTRLs did not change their alcohol consumption. AUC for glucose during OGTT did not change in either group. C-peptide responses increased in the FP group (206 ± 24 vs 236 ± 17 min × nmol/L, P = 0.052) and the Matsuda index of insulin sensitivity decreased (6.2 ± 2.4 vs 4.7 ± 1.4, P = 0.054). AUC for glucagon during oral glucose tolerance test (OGTT) increased in the FP group (1037 ± 90 vs 1562 ± 195 min × pmol/L, P = 0.003) together with fasting fibroblast growth factor 21 (FGF21) (62 ± 30 vs 132 ± 72 pmol/L, P < 0.001), growth differentiation factor 15 (GDF5) (276 ± 78 vs 330 ± 83 pg/mL, P = 0.009) and aspartate aminotransferase (AST) levels (37.6 ± 6.8 vs 42.4 ± 11 U/L, P = 0.043). Four participants (29%) developed ultrasound-detectable steatosis and a mean strain elastography-assessed liver stiffness increased (P = 0.026) in the FP group.Conclusions/Interpretation: Participation in Roskilde Festival did not affect oral glucose tolerance but was associated with a reduction in insulin sensitivity, increases in glucagon, FGF21, GDF15 and AST and lead to increased liver stiffness and, in 29% of the participants, ultrasound-detectable hepatic steatosis.

AB - Aims/hypothesis: Metabolic effects of intermittent unhealthy lifestyle in young adults are poorly studied. We investigated the gluco-metabolic and hepatic effects of participation in Roskilde Festival (1 week of binge drinking and junk food consumption) in young, healthy males.Methods: Fourteen festival participants (FP) were studied before, during and after 1 week's participation in Roskilde Festival. Fourteen matched controls (CTRL) who did not participate in Roskilde Festival or change their lifestyle in other ways were investigated along a similar timeline.Results: The FP group consumed more alcohol compared to their standard living conditions (2.0 ± 3.9 vs 16.3 ± 8.3 units/day, P < 0.001). CTRLs did not change their alcohol consumption. AUC for glucose during OGTT did not change in either group. C-peptide responses increased in the FP group (206 ± 24 vs 236 ± 17 min × nmol/L, P = 0.052) and the Matsuda index of insulin sensitivity decreased (6.2 ± 2.4 vs 4.7 ± 1.4, P = 0.054). AUC for glucagon during oral glucose tolerance test (OGTT) increased in the FP group (1037 ± 90 vs 1562 ± 195 min × pmol/L, P = 0.003) together with fasting fibroblast growth factor 21 (FGF21) (62 ± 30 vs 132 ± 72 pmol/L, P < 0.001), growth differentiation factor 15 (GDF5) (276 ± 78 vs 330 ± 83 pg/mL, P = 0.009) and aspartate aminotransferase (AST) levels (37.6 ± 6.8 vs 42.4 ± 11 U/L, P = 0.043). Four participants (29%) developed ultrasound-detectable steatosis and a mean strain elastography-assessed liver stiffness increased (P = 0.026) in the FP group.Conclusions/Interpretation: Participation in Roskilde Festival did not affect oral glucose tolerance but was associated with a reduction in insulin sensitivity, increases in glucagon, FGF21, GDF15 and AST and lead to increased liver stiffness and, in 29% of the participants, ultrasound-detectable hepatic steatosis.

KW - Adult

KW - Aspartate Aminotransferases/metabolism

KW - Binge Drinking/metabolism

KW - Blood Glucose/metabolism

KW - C-Peptide/metabolism

KW - C-Reactive Protein/metabolism

KW - Denmark

KW - Diet

KW - Elasticity Imaging Techniques

KW - Fast Foods

KW - Fatty Liver/diagnostic imaging

KW - Fibroblast Growth Factors/metabolism

KW - Glucagon/metabolism

KW - Glucose Tolerance Test

KW - Growth Differentiation Factor 15/metabolism

KW - Holidays

KW - Humans

KW - Insulin Resistance

KW - Liver/diagnostic imaging

KW - Male

KW - Young Adult

UR - http://www.scopus.com/inward/record.url?scp=85107088420&partnerID=8YFLogxK

U2 - 10.1530/EJE-21-0122

DO - 10.1530/EJE-21-0122

M3 - Journal article

C2 - 33886497

VL - 185

SP - 23

EP - 32

JO - European Journal of Endocrinology

JF - European Journal of Endocrinology

SN - 0804-4643

IS - 1

ER -

ID: 65895981