Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Metabolic control and sex: A focus on inflammatory-linked mediators

Research output: Contribution to journalReviewResearchpeer-review

DOI

  1. Different mechanisms involved in liraglutide and glucagon-like peptide-1 vasodilatation in rat mesenteric small arteries

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Characterization of binding, functional activity, and contractile responses of the selective 5-HT1F receptor agonist lasmiditan

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Silent Hypoxia in Patients with SARS CoV-2 Infection before Hospital Discharge

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Svær adenoviruspneumoni hos en immunkompetent mand

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Use of antidepressants in women after prophylactic bilateral oophorectomy: A Danish national cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

BACKGROUND AND PURPOSE: Men and women have many differing biological and physiological characteristics. Thus, it is no surprise, that the control of metabolic processes and the mechanisms underlying metabolic-related diseases have sex-specific components. There is a clear metabolic sexual dimorphism in that up until mid-life, men have a far greater likelihood of acquiring cardio-metabolic disease than women. Following menopause, however, this difference is reduced, suggestive of a protective role of the female sex hormones.

EXPERIMENTAL APPROACH: Inflammatory processes have been implicated in the pathogenesis of cardio-metabolic disease with human studies correlating metabolic disease acquisition or risk with levels of various inflammatory markers. Rodent studies employing genetic modifications or novel pharmacological approaches have provided mechanistic insight into the role of these inflammatory mediators. Sex differences impact inflammatory processes and the subsequent biological response. As a consequence, this may affect how inflammation alters metabolic processes between the sexes.

KEY RESULTS: Recently, some of our work in the field of inflammatory genes and metabolic control identified a sexual dimorphism in a pre-clinical model and caused us to question the frequency and scale of such findings in the literature. This review concentrates on inflammatory-related signalling in relation to obesity, insulin resistance and type 2 diabetes and highlights the differences observed between males and females.

CONCLUSIONS & IMPLICATIONS: Differences in the activation and signalling of various inflammatory genes and proteins presents another reason why studying both male and female patients or animals is important in the context of understanding and finding therapeutics for metabolic-related disease.

Original languageEnglish
JournalBritish Journal of Pharmacology
Volume176
Issue number21
Pages (from-to)4193-4207
ISSN0007-1188
DOIs
Publication statusPublished - Nov 2019

Bibliographical note

© 2019 The British Pharmacological Society.

ID: 56757523