Meta-analysis confirms the LCE3C_LCE3B deletion as a risk factor for psoriasis in several ethnic groups and finds interaction with HLA-Cw6

Eva Riveira-Munoz; Su-Min He; Georgia Escaramís; Philip E Stuart; Ulrike Hüffmeier; Catherine Lee; Brian Kirby; Akira Oka; Emiliano Giardina; Wilson Liao; Judith Bergboer; Kati Kainu; Rafael de Cid; Batmunkh Munkhbat; Patrick L J M Zeeuwen; John A L Armour; Annie Poon; Tomotaka Mabuchi; Akira Ozawa; Agnieszka Zawirska; A David Burden; Jonathan N Barker; Francesca Capon; Heiko Traupe; Liang-Dan Sun; Yong Cui; Xian-Yong Yin; Gang Chen; Henry W Lim; Rajan P Nair; John J Voorhees; Trilokraj Tejasvi; Ramón Pujol; Namid Munkhtuvshin; Judith Fischer; Juha Kere; Joost Schalkwijk; Anne Bowcock; Pui-Yan Kwok; Giuseppe Novelli; Hidetoshi Inoko; Anthony W Ryan; Richard C Trembath; André Reis; Xue-Jun Zhang; James T Elder; Xavier Estivill

doi:10.1038/jid.2010.350

Meta-analysis confirms the LCE3C_LCE3B deletion as a risk factor for psoriasis in several ethnic groups and finds interaction with HLA-Cw6

Eva Riveira-Munoz, Su-Min He, Georgia Escaramís, Philip E Stuart, Ulrike Hüffmeier, Catherine Lee, Brian Kirby, Akira Oka, Emiliano Giardina, Wilson Liao, Judith Bergboer, Kati Kainu, Rafael de Cid, Batmunkh Munkhbat, Patrick L J M Zeeuwen, John A L Armour, Annie Poon, Tomotaka Mabuchi, Akira Ozawa, Agnieszka ZawirskaA David Burden, Jonathan N Barker, Francesca Capon, Heiko Traupe, Liang-Dan Sun, Yong Cui, Xian-Yong Yin, Gang Chen, Henry W Lim, Rajan P Nair, John J Voorhees, Trilokraj Tejasvi, Ramón Pujol, Namid Munkhtuvshin, Judith Fischer, Juha Kere, Joost Schalkwijk, Anne Bowcock, Pui-Yan Kwok, Giuseppe Novelli, Hidetoshi Inoko, Anthony W Ryan, Richard C Trembath, André Reis, Xue-Jun Zhang, James T Elder, Xavier Estivill

Dermatology and Allergy

Abstract

A multicenter meta-analysis including data from 9,389 psoriasis patients and 9,477 control subjects was performed to investigate the contribution of the deletion of genes LCE3C and LCE3B, involved in skin barrier defense, to psoriasis susceptibility in different populations. The study confirms that the deletion of LCE3C and LCE3B is a common genetic factor for susceptibility to psoriasis in the European populations (OR(Overall) = 1.21 (1.15-1.27)), and for the first time directly demonstrates the deletion's association with psoriasis in the Chinese (OR = 1.27 (1.16-1.34)) and Mongolian (OR = 2.08 (1.44-2.99)) populations. The analysis of the HLA-Cw6 locus showed significant differences in the epistatic interaction with the LCE3C and LCE3B deletion in at least some European populations, indicating epistatic effects between these two major genetic contributors to psoriasis. The study highlights the value of examining genetic risk factors in multiple populations to identify genetic interactions, and indicates the need of further studies to understand the interaction of the skin barrier and the immune system in susceptibility to psoriasis.

Original language	English
Journal	The Journal of investigative dermatology
Volume	131
Issue number	5
Pages (from-to)	1105-9
Number of pages	5
ISSN	0022-202X
DOIs	https://doi.org/10.1038/jid.2010.350
Publication status	Published - May 2011

Keywords

Adolescent
Adult
Asian Continental Ancestry Group/genetics
Cornified Envelope Proline-Rich Proteins/genetics
Epistasis, Genetic
European Continental Ancestry Group/genetics
Female
Gene Deletion
Gene Frequency
Genetic Predisposition to Disease
HLA-C Antigens/genetics
Humans
Male
Polymorphism, Single Nucleotide
Psoriasis/genetics
Risk Factors
Young Adult

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Riveira-Munoz, E., He, S.-M., Escaramís, G., Stuart, P. E., Hüffmeier, U., Lee, C., Kirby, B., Oka, A., Giardina, E., Liao, W., Bergboer, J., Kainu, K., de Cid, R., Munkhbat, B., Zeeuwen, P. L. J. M., Armour, J. A. L., Poon, A., Mabuchi, T., Ozawa, A., ... Estivill, X. (2011). Meta-analysis confirms the LCE3C_LCE3B deletion as a risk factor for psoriasis in several ethnic groups and finds interaction with HLA-Cw6. The Journal of investigative dermatology, 131(5), 1105-9. https://doi.org/10.1038/jid.2010.350

Meta-analysis confirms the LCE3C_LCE3B deletion as a risk factor for psoriasis in several ethnic groups and finds interaction with HLA-Cw6. / Riveira-Munoz, Eva; He, Su-Min; Escaramís, Georgia et al.
In: The Journal of investigative dermatology, Vol. 131, No. 5, 05.2011, p. 1105-9.

Research output: Contribution to journal › Journal article › Research › peer-review

Riveira-Munoz, E, He, S-M, Escaramís, G, Stuart, PE, Hüffmeier, U, Lee, C, Kirby, B, Oka, A, Giardina, E, Liao, W, Bergboer, J, Kainu, K, de Cid, R, Munkhbat, B, Zeeuwen, PLJM, Armour, JAL, Poon, A, Mabuchi, T, Ozawa, A, Zawirska, A, Burden, AD, Barker, JN, Capon, F, Traupe, H, Sun, L-D, Cui, Y, Yin, X-Y, Chen, G, Lim, HW, Nair, RP, Voorhees, JJ, Tejasvi, T, Pujol, R, Munkhtuvshin, N, Fischer, J, Kere, J, Schalkwijk, J, Bowcock, A, Kwok, P-Y, Novelli, G, Inoko, H, Ryan, AW, Trembath, RC, Reis, A, Zhang, X-J, Elder, JT & Estivill, X 2011, 'Meta-analysis confirms the LCE3C_LCE3B deletion as a risk factor for psoriasis in several ethnic groups and finds interaction with HLA-Cw6', The Journal of investigative dermatology, vol. 131, no. 5, pp. 1105-9. https://doi.org/10.1038/jid.2010.350

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abstract = "A multicenter meta-analysis including data from 9,389 psoriasis patients and 9,477 control subjects was performed to investigate the contribution of the deletion of genes LCE3C and LCE3B, involved in skin barrier defense, to psoriasis susceptibility in different populations. The study confirms that the deletion of LCE3C and LCE3B is a common genetic factor for susceptibility to psoriasis in the European populations (OR(Overall) = 1.21 (1.15-1.27)), and for the first time directly demonstrates the deletion's association with psoriasis in the Chinese (OR = 1.27 (1.16-1.34)) and Mongolian (OR = 2.08 (1.44-2.99)) populations. The analysis of the HLA-Cw6 locus showed significant differences in the epistatic interaction with the LCE3C and LCE3B deletion in at least some European populations, indicating epistatic effects between these two major genetic contributors to psoriasis. The study highlights the value of examining genetic risk factors in multiple populations to identify genetic interactions, and indicates the need of further studies to understand the interaction of the skin barrier and the immune system in susceptibility to psoriasis.",

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author = "Eva Riveira-Munoz and Su-Min He and Georgia Escaram{\'i}s and Stuart, {Philip E} and Ulrike H{\"u}ffmeier and Catherine Lee and Brian Kirby and Akira Oka and Emiliano Giardina and Wilson Liao and Judith Bergboer and Kati Kainu and {de Cid}, Rafael and Batmunkh Munkhbat and Zeeuwen, {Patrick L J M} and Armour, {John A L} and Annie Poon and Tomotaka Mabuchi and Akira Ozawa and Agnieszka Zawirska and Burden, {A David} and Barker, {Jonathan N} and Francesca Capon and Heiko Traupe and Liang-Dan Sun and Yong Cui and Xian-Yong Yin and Gang Chen and Lim, {Henry W} and Nair, {Rajan P} and Voorhees, {John J} and Trilokraj Tejasvi and Ram{\'o}n Pujol and Namid Munkhtuvshin and Judith Fischer and Juha Kere and Joost Schalkwijk and Anne Bowcock and Pui-Yan Kwok and Giuseppe Novelli and Hidetoshi Inoko and Ryan, {Anthony W} and Trembath, {Richard C} and Andr{\'e} Reis and Xue-Jun Zhang and Elder, {James T} and Xavier Estivill",

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AU - He, Su-Min

AU - Escaramís, Georgia

AU - Stuart, Philip E

AU - Hüffmeier, Ulrike

AU - Lee, Catherine

AU - Kirby, Brian

AU - Oka, Akira

AU - Giardina, Emiliano

AU - Liao, Wilson

AU - Bergboer, Judith

AU - Kainu, Kati

AU - de Cid, Rafael

AU - Munkhbat, Batmunkh

AU - Zeeuwen, Patrick L J M

AU - Armour, John A L

AU - Poon, Annie

AU - Mabuchi, Tomotaka

AU - Ozawa, Akira

AU - Zawirska, Agnieszka

AU - Burden, A David

AU - Barker, Jonathan N

AU - Capon, Francesca

AU - Traupe, Heiko

AU - Sun, Liang-Dan

AU - Cui, Yong

AU - Yin, Xian-Yong

AU - Chen, Gang

AU - Lim, Henry W

AU - Nair, Rajan P

AU - Voorhees, John J

AU - Tejasvi, Trilokraj

AU - Pujol, Ramón

AU - Munkhtuvshin, Namid

AU - Fischer, Judith

AU - Kere, Juha

AU - Schalkwijk, Joost

AU - Bowcock, Anne

AU - Kwok, Pui-Yan

AU - Novelli, Giuseppe

AU - Inoko, Hidetoshi

AU - Ryan, Anthony W

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AU - Elder, James T

AU - Estivill, Xavier

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N2 - A multicenter meta-analysis including data from 9,389 psoriasis patients and 9,477 control subjects was performed to investigate the contribution of the deletion of genes LCE3C and LCE3B, involved in skin barrier defense, to psoriasis susceptibility in different populations. The study confirms that the deletion of LCE3C and LCE3B is a common genetic factor for susceptibility to psoriasis in the European populations (OR(Overall) = 1.21 (1.15-1.27)), and for the first time directly demonstrates the deletion's association with psoriasis in the Chinese (OR = 1.27 (1.16-1.34)) and Mongolian (OR = 2.08 (1.44-2.99)) populations. The analysis of the HLA-Cw6 locus showed significant differences in the epistatic interaction with the LCE3C and LCE3B deletion in at least some European populations, indicating epistatic effects between these two major genetic contributors to psoriasis. The study highlights the value of examining genetic risk factors in multiple populations to identify genetic interactions, and indicates the need of further studies to understand the interaction of the skin barrier and the immune system in susceptibility to psoriasis.

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KW - European Continental Ancestry Group/genetics

KW - Female

KW - Gene Deletion

KW - Gene Frequency

KW - Genetic Predisposition to Disease

KW - HLA-C Antigens/genetics

KW - Humans

KW - Male

KW - Polymorphism, Single Nucleotide

KW - Psoriasis/genetics

KW - Risk Factors

KW - Young Adult

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DO - 10.1038/jid.2010.350

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JO - The Journal of investigative dermatology

JF - The Journal of investigative dermatology

IS - 5

ER -

Meta-analysis confirms the LCE3C_LCE3B deletion as a risk factor for psoriasis in several ethnic groups and finds interaction with HLA-Cw6

Abstract

Keywords

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