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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Mesenchymal stromal cell derived endothelial progenitor treatment in patients with refractory angina

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  1. 30-day mortality in frail patients undergoing cardiac surgery: the results of the frailty in cardiac surgery (FICS) copenhagen study

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  2. Relationship Between Invasive Hemodynamics and Liver Function in Advanced Heart Failure

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  3. Atrial fibrillation and anticoagulation in patients with breast cancer

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  4. A national needs assessment study to determine procedures for simulation-based training in cardiology in Denmark

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  5. Contemporary practice of CRT implantation in scandinavia compared to Europe

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  1. Prognosis and Reclassification by YKL-40 in Stable Coronary Artery Disease

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  2. Relation of cardiac adipose tissue to coronary calcification and myocardial microvascular function in type 1 and type 2 diabetes

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  3. Soluble Markers of Interleukin 1 Activation as Predictors of First-Time Myocardial Infarction in HIV-Infected Individuals

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  4. FDG-PET/CT in the surveillance of head and neck cancer following radiotherapy

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Abstract Aims. We evaluated the feasibility, safety and efficacy of intra-myocardial injection of autologous mesenchymal stromal cells derived endothelial progenitor cell (MSC) in patients with stable coronary artery disease (CAD) and refractory angina in this first in man trial. Methods and results. A total of 31 patients with stable CAD, moderate to severe angina and no further revascularization options, were included. Bone marrow MSC were isolated and culture expanded for 6-8 weeks. It was feasible and safe to establish in-hospital culture expansion of autologous MSC and perform intra-myocardial injection of MSC. After six months follow-up myocardial perfusion was unaltered, but the patients increased exercise capacity (p <0.001), reduction in CCS Class (p <0.001), angina attacks (p <0.001) and nitroglycerin consumption (p <0.001), and improved Seattle Angina Questionnaire (SAQ) evaluations (p <0.001). For all parameters there was a tendency towards improved outcome with increasing numbers of cells injected. In the MRI substudy: ejection fraction (p <0.001), systolic wall thickness (p = 0.03) and wall thickening (p = 0.03) all improved. Conclusions. The study demonstrated that it was safe to treat patients with stable CAD with autologous culture expanded MSC. Moreover, MSC treated patients had significant improvement in left ventricular function and exercise capacity, in addition to an improvement in clinical symptoms and SAQ evaluations.
Original languageEnglish
JournalScandinavian Cardiovascular Journal
Volume45
Issue number3
Pages (from-to)161-8
Number of pages8
ISSN1401-7431
DOIs
Publication statusPublished - 1 Jun 2011

ID: 32357656