Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Mesenchymal Stem Cell Therapy for Osteoradionecrosis of the Mandible: a Systematic Review of Preclinical and Human Studies

Research output: Contribution to journalReviewResearchpeer-review

  1. An In Vitro Differentiation Protocol for Human Embryonic Bipotential Gonad and Testis Cell Development

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Patient iPSC-Derived Neurons for Disease Modeling of Frontotemporal Dementia with Mutation in CHMP2B

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Transient p53 suppression increases reprogramming of human fibroblasts without affecting apoptosis and DNA damage

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Mesenchymal stromal cell phenotype is not influenced by confluence during culture expansion

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Impact of human papillomavirus in sinonasal cancer-a systematic review

    Research output: Contribution to journalReviewResearchpeer-review

  2. Systemic Immune Profile in Patients With CRSwNP

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Methods for collecting upper respiratory tract specimens for COVID-19 diagnostics

    Research output: Contribution to journalReviewResearchpeer-review

View graph of relations

BACKGROUND: Osteoradionecrosis (ORN) of the mandible is a severe complication of radiotherapy for head and neck cancer and is arduously difficult to manage. Current treatment options carry risks with some patients remaining incurable. Mesenchymal stromal/stem cell (MSC) therapy has shown promising results supporting osteogenesis and regeneration of radiotherapy-damaged tissues. The aim of this study was to systematically review the literature on the safety and efficacy of MSCs in treating ORN.

METHODS: A systematic search was performed on MEDLINE, Embase, Cochranes Library online databases, and clinicaltrials.gov to identify preclinical and clinical studies examining the effect of MSCs on osseous healing of ORN. The preclinical studies were assessed according to the SYRCLEs guidelines and risk of bias tool.

RESULTS: Six studies (n = 142) from 5 countries were eligible for analysis. Of these four were preclinical studies and two clinical case studies. Preclinical studies found MSC treatment to be safe, demonstrating bone restorative effects and improved soft tissue regeneration. In the clinical cases, healing of bone and soft tissue was reported with no serious adverse events.

CONCLUSION: The evidence from the included studies suggests that MSCs may have beneficial regenerative effects on the healing of ORN. None of the studies reported adverse events with the use of MSCs. More carefully controlled studies with well-identified cells are however needed to demonstrate the efficacy of MSCs in a clinical setting. Graphical abstract.

Original languageEnglish
JournalStem Cell Reviews and Reports
Volume16
Issue number6
Pages (from-to)1208-1221
Number of pages14
ISSN1550-8943
DOIs
Publication statusPublished - Dec 2020

    Research areas

  • Cell therapy, Mesenchymal stem cells, ORN, Osteoradionecrosis, Systematic review

ID: 60788708