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Meropenem to Children With Febrile Neutropenia Induces Monoresistant Pseudomonas aeruginosa

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@article{f94ff17e1ab9442bbf32508d498ad560,
title = "Meropenem to Children With Febrile Neutropenia Induces Monoresistant Pseudomonas aeruginosa",
abstract = "Antimicrobial resistance in Pseudomonas aeruginosa is a threat to children with cancer. We explored the association between P. aeruginosa resistance and previous antibiotic exposure. All children with cancer and P. aeruginosa bacteremia in 2007 to 2016 in Denmark, a country with an overall resistance rate of ∼3%, were included. Twenty percent (10/49) of isolates from children previously exposed to meropenem were meropenem nonsusceptible. The only significant risk factor of meropenem nonsusceptibility was previous meropenem therapy (P=0.03). On the basis of these results, we suggest that meropenem should be reserved as a last resort for children with febrile neutropenia in countries with low antimicrobial resistance.",
keywords = "Adolescent, Anti-Bacterial Agents/adverse effects, Child, Child, Preschool, Denmark/epidemiology, Febrile Neutropenia/drug therapy, Female, Follow-Up Studies, Humans, Infant, Infant, Newborn, Male, Meropenem/adverse effects, Microbial Sensitivity Tests, Prognosis, Pseudomonas Infections/chemically induced, Pseudomonas aeruginosa/drug effects, Retrospective Studies, febrile neutropenia, antimicrobial resistance, empiric antibiotic therapy, infections",
author = "M{\o}nster, {Mette B} and Vissing, {Nadja H} and Henrik Schr{\o}der and Dorthe Grosen and Steen Rosth{\o}j and Niels Frimodt-M{\o}ller and Mikala Wang and Sch{\o}nheyder, {Henrik C} and Kjeld Schmiegelow and Justesen, {Ulrik S} and Ulrikka Nygaard",
year = "2020",
month = nov,
doi = "10.1097/MPH.0000000000001713",
language = "English",
volume = "42",
pages = "e783--e787",
journal = "Journal of Pediatric Hematology / Oncology",
issn = "1077-4114",
publisher = "Lippincott Williams & Wilkins",
number = "8",

}

RIS

TY - JOUR

T1 - Meropenem to Children With Febrile Neutropenia Induces Monoresistant Pseudomonas aeruginosa

AU - Mønster, Mette B

AU - Vissing, Nadja H

AU - Schrøder, Henrik

AU - Grosen, Dorthe

AU - Rosthøj, Steen

AU - Frimodt-Møller, Niels

AU - Wang, Mikala

AU - Schønheyder, Henrik C

AU - Schmiegelow, Kjeld

AU - Justesen, Ulrik S

AU - Nygaard, Ulrikka

PY - 2020/11

Y1 - 2020/11

N2 - Antimicrobial resistance in Pseudomonas aeruginosa is a threat to children with cancer. We explored the association between P. aeruginosa resistance and previous antibiotic exposure. All children with cancer and P. aeruginosa bacteremia in 2007 to 2016 in Denmark, a country with an overall resistance rate of ∼3%, were included. Twenty percent (10/49) of isolates from children previously exposed to meropenem were meropenem nonsusceptible. The only significant risk factor of meropenem nonsusceptibility was previous meropenem therapy (P=0.03). On the basis of these results, we suggest that meropenem should be reserved as a last resort for children with febrile neutropenia in countries with low antimicrobial resistance.

AB - Antimicrobial resistance in Pseudomonas aeruginosa is a threat to children with cancer. We explored the association between P. aeruginosa resistance and previous antibiotic exposure. All children with cancer and P. aeruginosa bacteremia in 2007 to 2016 in Denmark, a country with an overall resistance rate of ∼3%, were included. Twenty percent (10/49) of isolates from children previously exposed to meropenem were meropenem nonsusceptible. The only significant risk factor of meropenem nonsusceptibility was previous meropenem therapy (P=0.03). On the basis of these results, we suggest that meropenem should be reserved as a last resort for children with febrile neutropenia in countries with low antimicrobial resistance.

KW - Adolescent

KW - Anti-Bacterial Agents/adverse effects

KW - Child

KW - Child, Preschool

KW - Denmark/epidemiology

KW - Febrile Neutropenia/drug therapy

KW - Female

KW - Follow-Up Studies

KW - Humans

KW - Infant

KW - Infant, Newborn

KW - Male

KW - Meropenem/adverse effects

KW - Microbial Sensitivity Tests

KW - Prognosis

KW - Pseudomonas Infections/chemically induced

KW - Pseudomonas aeruginosa/drug effects

KW - Retrospective Studies

KW - febrile neutropenia

KW - antimicrobial resistance

KW - empiric antibiotic therapy

KW - infections

UR - http://www.scopus.com/inward/record.url?scp=85078205828&partnerID=8YFLogxK

U2 - 10.1097/MPH.0000000000001713

DO - 10.1097/MPH.0000000000001713

M3 - Journal article

C2 - 31972720

VL - 42

SP - e783-e787

JO - Journal of Pediatric Hematology / Oncology

JF - Journal of Pediatric Hematology / Oncology

SN - 1077-4114

IS - 8

ER -

ID: 62063794