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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Meropenem to Children With Febrile Neutropenia Induces Monoresistant Pseudomonas aeruginosa

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  1. Abdominal Complications During Treatment for Pediatric Acute Myeloid Leukemia

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  2. Can Machine Learning Models Predict Asparaginase-associated Pancreatitis in Childhood Acute Lymphoblastic Leukemia

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  3. Improved Survival of Children, Adolescents, and Young Adults With Head and Neck Soft Tissue Sarcomas in Denmark

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  4. Hearing Status in Survivors of Childhood Acute Myeloid Leukemia Treated With Chemotherapy Only: A NOPHO-AML Study

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  1. EXABS-103-ALL Advances in ALL Diagnosis and Treatment -The NOPHO Experience

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  2. Vaginal microbiome following orally administered probiotic

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  3. Cancer-related Mutations with Local or Long-range Effects on an Allosteric Loop of p53

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  4. Dentist's visits and risk of brain abscess: a nationwide, population-based case control study

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Antimicrobial resistance in Pseudomonas aeruginosa is a threat to children with cancer. We explored the association between P. aeruginosa resistance and previous antibiotic exposure. All children with cancer and P. aeruginosa bacteremia in 2007 to 2016 in Denmark, a country with an overall resistance rate of ∼3%, were included. Twenty percent (10/49) of isolates from children previously exposed to meropenem were meropenem nonsusceptible. The only significant risk factor of meropenem nonsusceptibility was previous meropenem therapy (P=0.03). On the basis of these results, we suggest that meropenem should be reserved as a last resort for children with febrile neutropenia in countries with low antimicrobial resistance.

Original languageEnglish
JournalJournal of Pediatric Hematology/Oncology
Volume42
Issue number8
Pages (from-to)e783-e787
ISSN1077-4114
DOIs
Publication statusPublished - Nov 2020

    Research areas

  • Adolescent, Anti-Bacterial Agents/adverse effects, Child, Child, Preschool, Denmark/epidemiology, Febrile Neutropenia/drug therapy, Female, Follow-Up Studies, Humans, Infant, Infant, Newborn, Male, Meropenem/adverse effects, Microbial Sensitivity Tests, Prognosis, Pseudomonas Infections/chemically induced, Pseudomonas aeruginosa/drug effects, Retrospective Studies, febrile neutropenia, antimicrobial resistance, empiric antibiotic therapy, infections

ID: 62063794