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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Mental vulnerability--a risk factor for ischemic heart disease.

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  • Lene Falgaard Eplov
  • Torben Jørgensen
  • Morten Birket-Smith
  • Janne Petersen
  • Christoffer Johansen
  • Erik Lykke Mortensen
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OBJECTIVE: The purpose of this study is to examine whether mental vulnerability is a risk factor for the development of ischemic heart disease (IHD) after adjustment for well-established risk factors. METHODS: In three prospective cohort studies in Copenhagen County, Denmark, we recorded the level of mental vulnerability and possible risk factors to IHD at baseline. For follow-up, the sample was linked to relevant registries to identify all cases of fatal and nonfatal IHD. The relationship between mental vulnerability and IHD was examined using both Kaplan-Meir and Cox proportional hazard models adjusting for possible confounding factors. RESULTS: Mental vulnerability was significantly associated with the risk for IHD (medium mental vulnerability: hazard ratio 1.41, 95% confidence interval 1.04-1.91; and high mental vulnerability: hazard ratio 2.05; 95% confidence interval 1.46-2.88), after adjusting for confounders. CONCLUSION: Our results imply that mental vulnerability is an independent risk factor for IHD.
Udgivelsesdato: 2006-Feb
Original languageEnglish
JournalJournal of Psychosomatic Research
Volume60
Issue number2
Pages (from-to)169-76
Number of pages7
ISSN0022-3999
DOIs
Publication statusPublished - 2006

    Research areas

  • Adult, Aged, Cause of Death, Cohort Studies, Comorbidity, Denmark, Female, Follow-Up Studies, Health Surveys, Humans, Male, Middle Aged, Myocardial Ischemia, Personality Inventory, Proportional Hazards Models, Psychophysiologic Disorders, Referral and Consultation, Risk Factors, Vulnerable Populations

ID: 32517794