Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Menstrual pain and risk of epithelial ovarian cancer: Results from the Ovarian Cancer Association Consortium

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Testicular cancer incidence predictions in Europe 2010–2035: A rising burden despite population ageing

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Tibolone and risk of gynecological hormone sensitive cancer

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Does HPV status influence survival after vulvar cancer?

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Long-term risk of cervical cancer following conization of cervical intraepithelial neoplasia grade 3-A Danish nationwide cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Human papillomavirus genotype-specific risks for cervical intraepithelial lesions

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Expanding our understanding of ovarian cancer risk: the role of incomplete pregnancies

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Borderline ovarian tumors in Denmark 1997-2018: Time trends in incidence by histology, age and educational level

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Low-dose aspirin use and risk of head and neck cancer-A Danish nationwide case-control study

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Endometrial cancer risk after fertility treatment: a population-based cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

  • Ana Babic
  • Holly R Harris
  • Allison F Vitonis
  • Linda J Titus
  • Susan J Jordan
  • Penelope M Webb
  • Harvey A Risch
  • Mary Anne Rossing
  • Jennifer A Doherty
  • Kristine Wicklund
  • Marc T Goodman
  • Francesmary Modugno
  • Kirsten B Moysich
  • Roberta B Ness
  • Susanne K Kjaer
  • Joellen Schildkraut
  • Andrew Berchuck
  • Celeste L Pearce
  • Anna H Wu
  • Daniel W Cramer
  • Kathryn L Terry
  • Australian Ovarian Cancer Study Group
View graph of relations

Menstrual pain, a common gynecological condition, has been associated with increased risk of ovarian cancer in some, but not all studies. Furthermore, potential variations in the association between menstrual pain and ovarian cancer by histologic subtype have not been adequately evaluated due to lack of power. We assessed menstrual pain using either direct questions about having experienced menstrual pain, or indirect questions about menstrual pain as indication for use of hormones or medications. We used multivariate logistic regression to calculate the odds ratio (OR) for the association between severe menstrual pain and ovarian cancer, adjusting for potential confounders and multinomial logistic regression to calculate ORs for specific histologic subtypes. We observed no association between ovarian cancer and menstrual pain assessed by indirect questions. Among studies using direct question, severe pain was associated with a small but significant increase in overall risk of ovarian cancer (OR = 1.07, 95% CI: 1.01-1.13), after adjusting for endometriosis and other potential confounders. The association appeared to be more relevant for clear cell (OR = 1.48, 95% CI: 1.10-1.99) and serous borderline (OR = 1.31, 95% CI: 1.05-1.63) subtypes. In this large international pooled analysis of case-control studies, we observed a small increase in risk of ovarian cancer for women reporting severe menstrual pain. While we observed an increased ovarian cancer risk with severe menstrual pain, the possibility of recall bias and undiagnosed endometriosis cannot be excluded. Future validation in prospective studies with detailed information on endometriosis is needed.

Original languageEnglish
JournalRadiation Oncology Investigations
Volume142
Issue number3
Pages (from-to)460-469
Number of pages10
ISSN0020-7136
DOIs
Publication statusPublished - 1 Feb 2018

    Research areas

  • Case-Control Studies, Dysmenorrhea, Female, Humans, Middle Aged, Neoplasms, Glandular and Epithelial, Ovarian Neoplasms, Risk, United States, Journal Article

ID: 52396773