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Melanopsin-mediated pupillary responses in bipolar disorder-a cross-sectional pupillometric investigation

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@article{396cd5de86044dfc9b844e6f998a226f,
title = "Melanopsin-mediated pupillary responses in bipolar disorder-a cross-sectional pupillometric investigation",
abstract = "BACKGROUND: Visible light, predominantly in the blue range, affects mood and circadian rhythm partly by activation of the melanopsin-containing intrinsically photosensitive retinal ganglion cells (ipRGCs). The light-induced responses of these ganglion cells can be evaluated by pupillometry. The study aimed to assess the blue light induced pupil constriction in patients with bipolar disorder (BD).METHODS: We investigated the pupillary responses to blue light by chromatic pupillometry in 31 patients with newly diagnosed bipolar disorder, 22 of their unaffected relatives and 35 healthy controls. Mood state was evaluated by interview-based ratings of depressive symptoms (Hamilton Depression Rating Scale) and (hypo-)manic symptoms (Young Mania Rating Scale).RESULTS: The ipRGC-mediated pupillary responses did not differ across the three groups, but subgroup analyses showed that patients in remission had reduced ipRGC-mediated responses compared with controls (9%, p = 0.04). Longer illness duration was associated with more pronounced ipRGC-responses (7% increase/10-year illness duration, p = 0.02).CONCLUSIONS: The ipRGC-mediated pupil response to blue light was reduced in euthymic patients compared with controls and increased with longer disease duration. Longitudinal studies are needed to corroborate these potential associations with illness state and/or progression.",
keywords = "Bipolar disorder, Circadian rhythm, Melanopsin, Mood disorders, Pupillary reflex, Pupillometry, Retina",
author = "Madsen, {Helle {\O}stergaard} and Shakoor Ba-Ali and Steffen Heegaard and Ida Hageman and Ulla Knorr and Henrik Lund-Andersen and Klaus Martiny and Kessing, {Lars Vedel}",
year = "2021",
month = mar,
day = "1",
doi = "10.1186/s40345-020-00211-3",
language = "English",
volume = "9",
pages = "7",
journal = "International Journal of Bipolar Disorders",
issn = "2194-7511",
publisher = "SpringerOpen",
number = "1",

}

RIS

TY - JOUR

T1 - Melanopsin-mediated pupillary responses in bipolar disorder-a cross-sectional pupillometric investigation

AU - Madsen, Helle Østergaard

AU - Ba-Ali, Shakoor

AU - Heegaard, Steffen

AU - Hageman, Ida

AU - Knorr, Ulla

AU - Lund-Andersen, Henrik

AU - Martiny, Klaus

AU - Kessing, Lars Vedel

PY - 2021/3/1

Y1 - 2021/3/1

N2 - BACKGROUND: Visible light, predominantly in the blue range, affects mood and circadian rhythm partly by activation of the melanopsin-containing intrinsically photosensitive retinal ganglion cells (ipRGCs). The light-induced responses of these ganglion cells can be evaluated by pupillometry. The study aimed to assess the blue light induced pupil constriction in patients with bipolar disorder (BD).METHODS: We investigated the pupillary responses to blue light by chromatic pupillometry in 31 patients with newly diagnosed bipolar disorder, 22 of their unaffected relatives and 35 healthy controls. Mood state was evaluated by interview-based ratings of depressive symptoms (Hamilton Depression Rating Scale) and (hypo-)manic symptoms (Young Mania Rating Scale).RESULTS: The ipRGC-mediated pupillary responses did not differ across the three groups, but subgroup analyses showed that patients in remission had reduced ipRGC-mediated responses compared with controls (9%, p = 0.04). Longer illness duration was associated with more pronounced ipRGC-responses (7% increase/10-year illness duration, p = 0.02).CONCLUSIONS: The ipRGC-mediated pupil response to blue light was reduced in euthymic patients compared with controls and increased with longer disease duration. Longitudinal studies are needed to corroborate these potential associations with illness state and/or progression.

AB - BACKGROUND: Visible light, predominantly in the blue range, affects mood and circadian rhythm partly by activation of the melanopsin-containing intrinsically photosensitive retinal ganglion cells (ipRGCs). The light-induced responses of these ganglion cells can be evaluated by pupillometry. The study aimed to assess the blue light induced pupil constriction in patients with bipolar disorder (BD).METHODS: We investigated the pupillary responses to blue light by chromatic pupillometry in 31 patients with newly diagnosed bipolar disorder, 22 of their unaffected relatives and 35 healthy controls. Mood state was evaluated by interview-based ratings of depressive symptoms (Hamilton Depression Rating Scale) and (hypo-)manic symptoms (Young Mania Rating Scale).RESULTS: The ipRGC-mediated pupillary responses did not differ across the three groups, but subgroup analyses showed that patients in remission had reduced ipRGC-mediated responses compared with controls (9%, p = 0.04). Longer illness duration was associated with more pronounced ipRGC-responses (7% increase/10-year illness duration, p = 0.02).CONCLUSIONS: The ipRGC-mediated pupil response to blue light was reduced in euthymic patients compared with controls and increased with longer disease duration. Longitudinal studies are needed to corroborate these potential associations with illness state and/or progression.

KW - Bipolar disorder

KW - Circadian rhythm

KW - Melanopsin

KW - Mood disorders

KW - Pupillary reflex

KW - Pupillometry

KW - Retina

UR - http://www.scopus.com/inward/record.url?scp=85101867838&partnerID=8YFLogxK

U2 - 10.1186/s40345-020-00211-3

DO - 10.1186/s40345-020-00211-3

M3 - Journal article

C2 - 33644827

VL - 9

SP - 7

JO - International Journal of Bipolar Disorders

JF - International Journal of Bipolar Disorders

SN - 2194-7511

IS - 1

M1 - 7

ER -

ID: 64185483