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Melanopsin-expressing retinal ganglion cells are resistant to cell injury, but not always

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  1. Growth and differentiation factor 15 as a biomarker for mitochondrial myopathy

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  2. Muscle contractility of leg muscles in patients with mitochondrial myopathies

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  3. Mitochondrial dysfunction underlying outer retinal diseases

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  1. Mice Lacking EGR1 Have Impaired Clock Gene (BMAL1) Oscillation, Locomotor Activity, and Body Temperature

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  2. Døgnrytmer, søvn og søvnforstyrrelser

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  3. Localization, distribution, and connectivity of neuropeptide Y in the human and porcine retinas - a comparative study

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  4. Laser-induced thermal coagulation enhances skin uptake of topically applied compounds

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Melanopsin retinal ganglion cells (mRGCs) are intrinsically photosensitive RGCs deputed to non-image forming functions of the eye such as synchronization of circadian rhythms to light-dark cycle. These cells are characterized by unique electrophysiological, anatomical and biochemical properties and are usually more resistant than conventional RGCs to different insults, such as axotomy and different paradigms of stress. We also demonstrated that these cells are relatively spared compared to conventional RGCs in mitochondrial optic neuropathies (Leber's hereditary optic neuropathy and Dominant Optic Atrophy). However, these cells are affected in other neurodegenerative conditions, such as glaucoma and Alzheimer's disease. We here review the current evidences that may underlie this dichotomy. We also present our unpublished data on cell experiments demonstrating that melanopsin itself does not explain the robustness of these cells and some preliminary data on immunohistochemical assessment of mitochondria in mRGCs.

Original languageEnglish
JournalMitochondrion
Volume36
Pages (from-to)77-84
Number of pages8
ISSN1567-7249
DOIs
Publication statusPublished - Sep 2017

    Research areas

  • Journal Article

ID: 52158414