TY - JOUR
T1 - Medical oncological treatment for patients with Gastrointestinal Stromal Tumor (GIST) - A systematic review
AU - Brinch, Charlotte Margareta
AU - Aggerholm-Pedersen, Ninna
AU - Hogdall, Estrid
AU - Krarup-Hansen, Anders
N1 - Copyright © 2022 The Authors. Published by Elsevier B.V. All rights reserved.
PY - 2022/4
Y1 - 2022/4
N2 - BACKGROUND: Chemotherapy is ineffective in treating patients with Gastrointestinal Stromal Tumor (GIST). However, several types of tyrosine kinase inhibitors have been investigated since the approval of imatinib in 2001. The purpose of this report was to systematically review studies on the efficacy of neoadjuvant, adjuvant, and lifelong medical oncological treatment of GIST.METHODS: The Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines were followed throughout the review process. The protocol was submitted to the International prospective register of systematic reviews database (ID 251724). A systematic literature search was performed, including phase II- and III studies of biological treatment, reporting on treatment effect in patients with GIST.RESULTS: Of 308 identified publications, 42 studies were included in this review.CONCLUSION: This review gives an overview of the existing evidence for approved lines of oncological treatments and potential alternatives for patients with GIST in the neoadjuvant-, adjuvant- and life-long setting.
AB - BACKGROUND: Chemotherapy is ineffective in treating patients with Gastrointestinal Stromal Tumor (GIST). However, several types of tyrosine kinase inhibitors have been investigated since the approval of imatinib in 2001. The purpose of this report was to systematically review studies on the efficacy of neoadjuvant, adjuvant, and lifelong medical oncological treatment of GIST.METHODS: The Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines were followed throughout the review process. The protocol was submitted to the International prospective register of systematic reviews database (ID 251724). A systematic literature search was performed, including phase II- and III studies of biological treatment, reporting on treatment effect in patients with GIST.RESULTS: Of 308 identified publications, 42 studies were included in this review.CONCLUSION: This review gives an overview of the existing evidence for approved lines of oncological treatments and potential alternatives for patients with GIST in the neoadjuvant-, adjuvant- and life-long setting.
KW - Antineoplastic Agents/pharmacology
KW - Benzamides/therapeutic use
KW - Gastrointestinal Neoplasms/drug therapy
KW - Gastrointestinal Stromal Tumors/drug therapy
KW - Humans
KW - Piperazines/therapeutic use
KW - Pyrimidines/therapeutic use
UR - http://www.scopus.com/inward/record.url?scp=85126338434&partnerID=8YFLogxK
U2 - 10.1016/j.critrevonc.2022.103650
DO - 10.1016/j.critrevonc.2022.103650
M3 - Review
C2 - 35283299
SN - 1040-8428
VL - 172
SP - 103650
JO - Critical Reviews in Oncology/Hematology
JF - Critical Reviews in Oncology/Hematology
M1 - 103650
ER -