Mechanisms of topoisomerase I (TOP1) gene copy number increase in a stage III colorectal cancer patient cohort

David Hersi Smith; Ib Jarle Christensen; Niels Frank Jensen; Thomas Bo Markussen; Maria Unni Koefoed Rømer; Sune Boris Nygård; Sven Müller; Hans Jørgen Nielsen; Nils Aage Brünner; Kirsten Vang Nielsen

doi:10.1371/journal.pone.0060613

Mechanisms of topoisomerase I (TOP1) gene copy number increase in a stage III colorectal cancer patient cohort

David Hersi Smith, Ib Jarle Christensen, Niels Frank Jensen, Thomas Bo Markussen, Maria Unni Koefoed Rømer, Sune Boris Nygård, Sven Müller, Hans Jørgen Nielsen, Nils Aage Brünner, Kirsten Vang Nielsen

23 Citations (Scopus)

Abstract

Topoisomerase I (Top1) is the target of Top1 inhibitor chemotherapy. The TOP1 gene, located at 20q12-q13.1, is frequently detected at elevated copy numbers in colorectal cancer (CRC). The present study explores the mechanism, frequency and prognostic impact of TOP1 gene aberrations in stage III CRC and how these can be detected by fluorescent in situ hybridization (FISH).

Original language	English
Journal	P L o S One
Volume	8
Issue number	4
Pages (from-to)	e60613
Number of pages	10
ISSN	1932-6203
DOIs	https://doi.org/10.1371/journal.pone.0060613
Publication status	Published - 2013

Keywords

Cell Line, Tumor
Chromosomes, Human, Pair 2
Chromosomes, Human, Pair 20
Cohort Studies
Colorectal Neoplasms
DNA Topoisomerases, Type I
Female
Gene Dosage
Humans
In Situ Hybridization, Fluorescence
Male
Middle Aged
Neoplasm Staging
Prognosis

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title = "Mechanisms of topoisomerase I (TOP1) gene copy number increase in a stage III colorectal cancer patient cohort",

abstract = "Topoisomerase I (Top1) is the target of Top1 inhibitor chemotherapy. The TOP1 gene, located at 20q12-q13.1, is frequently detected at elevated copy numbers in colorectal cancer (CRC). The present study explores the mechanism, frequency and prognostic impact of TOP1 gene aberrations in stage III CRC and how these can be detected by fluorescent in situ hybridization (FISH).",

keywords = "Cell Line, Tumor, Chromosomes, Human, Pair 2, Chromosomes, Human, Pair 20, Cohort Studies, Colorectal Neoplasms, DNA Topoisomerases, Type I, Female, Gene Dosage, Humans, In Situ Hybridization, Fluorescence, Male, Middle Aged, Neoplasm Staging, Prognosis",

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doi = "10.1371/journal.pone.0060613",

language = "English",

volume = "8",

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T1 - Mechanisms of topoisomerase I (TOP1) gene copy number increase in a stage III colorectal cancer patient cohort

AU - Smith, David Hersi

AU - Christensen, Ib Jarle

AU - Jensen, Niels Frank

AU - Markussen, Thomas Bo

AU - Rømer, Maria Unni Koefoed

AU - Nygård, Sune Boris

AU - Müller, Sven

AU - Nielsen, Hans Jørgen

AU - Brünner, Nils Aage

AU - Nielsen, Kirsten Vang

PY - 2013

Y1 - 2013

N2 - Topoisomerase I (Top1) is the target of Top1 inhibitor chemotherapy. The TOP1 gene, located at 20q12-q13.1, is frequently detected at elevated copy numbers in colorectal cancer (CRC). The present study explores the mechanism, frequency and prognostic impact of TOP1 gene aberrations in stage III CRC and how these can be detected by fluorescent in situ hybridization (FISH).

AB - Topoisomerase I (Top1) is the target of Top1 inhibitor chemotherapy. The TOP1 gene, located at 20q12-q13.1, is frequently detected at elevated copy numbers in colorectal cancer (CRC). The present study explores the mechanism, frequency and prognostic impact of TOP1 gene aberrations in stage III CRC and how these can be detected by fluorescent in situ hybridization (FISH).

KW - Cell Line, Tumor

KW - Chromosomes, Human, Pair 2

KW - Chromosomes, Human, Pair 20

KW - Cohort Studies

KW - Colorectal Neoplasms

KW - DNA Topoisomerases, Type I

KW - Female

KW - Gene Dosage

KW - Humans

KW - In Situ Hybridization, Fluorescence

KW - Male

KW - Middle Aged

KW - Neoplasm Staging

KW - Prognosis

U2 - 10.1371/journal.pone.0060613

DO - 10.1371/journal.pone.0060613

M3 - Journal article

C2 - 23577133

SN - 1932-6203

VL - 8

SP - e60613

JO - P L o S One

JF - P L o S One

IS - 4

ER -

Mechanisms of topoisomerase I (TOP1) gene copy number increase in a stage III colorectal cancer patient cohort

Abstract

Keywords

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