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Measurement of axonal excitability: Consensus guidelines

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  • Matthew C Kiernan
  • Hugh Bostock
  • Susanna B Park
  • Ryuji Kaji
  • Christian Krarup
  • Arun V Krishnan
  • Satoshi Kuwabara
  • Cindy Shin-Yi Lin
  • Sonoko Misawa
  • Mihai Moldovan
  • Jiaying Sung
  • Steve Vucic
  • Brian J Wainger
  • Stephen Waxman
  • David Burke
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Measurement of axonal excitability provides an in vivo indication of the properties of the nerve membrane and of the ion channels expressed on these axons. Axonal excitability techniques have been utilised to investigate the pathophysiological mechanisms underlying neurological diseases. This document presents guidelines derived for such studies, based on a consensus of international experts, and highlights the potential difficulties when interpreting abnormalities in diseased axons. The present manuscript provides a state-of-the-art review of the findings of axonal excitability studies and their interpretation, in addition to suggesting guidelines for the optimal performance of excitability studies.

Original languageEnglish
JournalClinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
Volume131
Issue number1
Pages (from-to)308-323
Number of pages16
ISSN1388-2457
DOIs
Publication statusPublished - Jan 2020

    Research areas

  • Action Potentials, Axons/physiology, Consensus, Electric Stimulation/instrumentation, Electrodes, Implanted, Equipment Design, Humans, Ion Channels/physiology, Membrane Potentials/physiology, Models, Neurological, Nervous System Diseases/physiopathology, Neurophysiology/instrumentation, Sensory Thresholds/physiology, Software

ID: 62083402