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Measles, mumps, rubella, and varicella-zoster virus serology and infections in solid organ transplant recipients during the first year post-transplantation

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@article{d7090c68de964216a114e92427ea3adc,
title = "Measles, mumps, rubella, and varicella-zoster virus serology and infections in solid organ transplant recipients during the first year post-transplantation",
abstract = "BACKGROUND: Mumps, measles, rubella, and varicella-zoster viruses (MMRV) may cause severe infections in seronegative adult solid organ transplant (SOT) recipients but can be prevented by vaccination. We aimed to determine MMRV serostatus in adult SOT recipients before and one-year post-transplantation as well as evidence of MMRV infections in a large, prospective cohort of SOT recipients.METHODS: A prospective study of 1182 adult SOT recipients included in the Management of Posttransplant Infections in Collaborating Hospitals (MATCH) cohort from 2011 to 2017 with a one-year follow-up. Systematic monitoring of MMRV serology was performed prior to transplantation and one-year post-transplantation. PCR was used to confirm viral replication in SOT-recipients presenting with clinical evidence of infection.RESULTS: Among 1182 adult SOT recipients, 28 (2.4{\%}), 77 (6.5{\%}), 65 (5.5{\%}), and 22 (1.9{\%}) were seronegative for measles, mumps, rubella, and VZV, respectively, and 165 (14{\%}) were seronegative for at least one of the MMRV viruses. One-year post-transplantation, 29/823 (3.5{\%}) of seropositive SOT recipients had seroreverted, and 63/111 (57{\%}) of seronegative SOT recipients seroconverted for at least one MMRV virus. No evidence of MMR infections was found, but 8 (0.7{\%}) SOT recipients developed symptoms and had a positive VZV PCR.CONCLUSIONS: A large proportion of SOT recipients were seronegative for at least one of the MMRV viruses. MMRV infections in SOT recipients may disseminate and become fatal, and although only few cases of VZV infection were detected, results from this study suggest increase attention towards vaccination of patients waiting for SOT.",
keywords = "Immunization, Organ transplant, Serology, Virus infection",
author = "Omid Rezahosseini and S{\o}rensen, {S{\o}ren Schwartz} and Michael Perch and Christina Ekenberg and M{\o}ller, {Dina Leth} and Knudsen, {Andreas Dehlb{\ae}k} and Nikolai Kirkby and Jens Lundgren and Lodding, {Isabelle P} and Wareham, {Neval Ete} and Finn Gustafsson and Allan Rasmussen and Nielsen, {Susanne Dam}",
note = "{\circledC} The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.",
year = "2020",
month = "6",
day = "21",
doi = "10.1093/cid/ciaa824",
language = "English",
journal = "Clinical Infectious Diseases",
issn = "1058-4838",
publisher = "University of Chicago Press",

}

RIS

TY - JOUR

T1 - Measles, mumps, rubella, and varicella-zoster virus serology and infections in solid organ transplant recipients during the first year post-transplantation

AU - Rezahosseini, Omid

AU - Sørensen, Søren Schwartz

AU - Perch, Michael

AU - Ekenberg, Christina

AU - Møller, Dina Leth

AU - Knudsen, Andreas Dehlbæk

AU - Kirkby, Nikolai

AU - Lundgren, Jens

AU - Lodding, Isabelle P

AU - Wareham, Neval Ete

AU - Gustafsson, Finn

AU - Rasmussen, Allan

AU - Nielsen, Susanne Dam

N1 - © The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.

PY - 2020/6/21

Y1 - 2020/6/21

N2 - BACKGROUND: Mumps, measles, rubella, and varicella-zoster viruses (MMRV) may cause severe infections in seronegative adult solid organ transplant (SOT) recipients but can be prevented by vaccination. We aimed to determine MMRV serostatus in adult SOT recipients before and one-year post-transplantation as well as evidence of MMRV infections in a large, prospective cohort of SOT recipients.METHODS: A prospective study of 1182 adult SOT recipients included in the Management of Posttransplant Infections in Collaborating Hospitals (MATCH) cohort from 2011 to 2017 with a one-year follow-up. Systematic monitoring of MMRV serology was performed prior to transplantation and one-year post-transplantation. PCR was used to confirm viral replication in SOT-recipients presenting with clinical evidence of infection.RESULTS: Among 1182 adult SOT recipients, 28 (2.4%), 77 (6.5%), 65 (5.5%), and 22 (1.9%) were seronegative for measles, mumps, rubella, and VZV, respectively, and 165 (14%) were seronegative for at least one of the MMRV viruses. One-year post-transplantation, 29/823 (3.5%) of seropositive SOT recipients had seroreverted, and 63/111 (57%) of seronegative SOT recipients seroconverted for at least one MMRV virus. No evidence of MMR infections was found, but 8 (0.7%) SOT recipients developed symptoms and had a positive VZV PCR.CONCLUSIONS: A large proportion of SOT recipients were seronegative for at least one of the MMRV viruses. MMRV infections in SOT recipients may disseminate and become fatal, and although only few cases of VZV infection were detected, results from this study suggest increase attention towards vaccination of patients waiting for SOT.

AB - BACKGROUND: Mumps, measles, rubella, and varicella-zoster viruses (MMRV) may cause severe infections in seronegative adult solid organ transplant (SOT) recipients but can be prevented by vaccination. We aimed to determine MMRV serostatus in adult SOT recipients before and one-year post-transplantation as well as evidence of MMRV infections in a large, prospective cohort of SOT recipients.METHODS: A prospective study of 1182 adult SOT recipients included in the Management of Posttransplant Infections in Collaborating Hospitals (MATCH) cohort from 2011 to 2017 with a one-year follow-up. Systematic monitoring of MMRV serology was performed prior to transplantation and one-year post-transplantation. PCR was used to confirm viral replication in SOT-recipients presenting with clinical evidence of infection.RESULTS: Among 1182 adult SOT recipients, 28 (2.4%), 77 (6.5%), 65 (5.5%), and 22 (1.9%) were seronegative for measles, mumps, rubella, and VZV, respectively, and 165 (14%) were seronegative for at least one of the MMRV viruses. One-year post-transplantation, 29/823 (3.5%) of seropositive SOT recipients had seroreverted, and 63/111 (57%) of seronegative SOT recipients seroconverted for at least one MMRV virus. No evidence of MMR infections was found, but 8 (0.7%) SOT recipients developed symptoms and had a positive VZV PCR.CONCLUSIONS: A large proportion of SOT recipients were seronegative for at least one of the MMRV viruses. MMRV infections in SOT recipients may disseminate and become fatal, and although only few cases of VZV infection were detected, results from this study suggest increase attention towards vaccination of patients waiting for SOT.

KW - Immunization

KW - Organ transplant

KW - Serology

KW - Virus infection

U2 - 10.1093/cid/ciaa824

DO - 10.1093/cid/ciaa824

M3 - Journal article

JO - Clinical Infectious Diseases

JF - Clinical Infectious Diseases

SN - 1058-4838

ER -

ID: 60097256