TY - JOUR
T1 - Maximal heart rate does not limit cardiovascular capacity in healthy humans
T2 - insight from right atrial pacing during maximal exercise
AU - Munch, Gregers D W
AU - Svendsen, Jesper H
AU - Damsgaard, Rasmus
AU - Secher, Niels H
AU - González-Alonso, José
AU - Mortensen, Stefan P
PY - 2014
Y1 - 2014
N2 - In humans, maximal aerobic power (VO2max) is associated with a plateau in cardiac output (Q), but the mechanisms regulating the interplay between maximal heart rate (HRmax) and stroke volume (SV) are unclear. To evaluate the effect of tachycardia and elevations in HRmax on cardiovascular function and capacity during maximal exercise in healthy humans, twelve young male cyclists performed incremental cycling and one-legged knee-extensor exercise (KEE) to exhaustion with and without right atrial pacing to increase HR. During control cycling, Q and leg blood flow increased up to 85% of maximal workload (WLmax) and remained unchanged until exhaustion. SV initially increased, plateaued and then decreased before exhaustion (P
AB - In humans, maximal aerobic power (VO2max) is associated with a plateau in cardiac output (Q), but the mechanisms regulating the interplay between maximal heart rate (HRmax) and stroke volume (SV) are unclear. To evaluate the effect of tachycardia and elevations in HRmax on cardiovascular function and capacity during maximal exercise in healthy humans, twelve young male cyclists performed incremental cycling and one-legged knee-extensor exercise (KEE) to exhaustion with and without right atrial pacing to increase HR. During control cycling, Q and leg blood flow increased up to 85% of maximal workload (WLmax) and remained unchanged until exhaustion. SV initially increased, plateaued and then decreased before exhaustion (P
U2 - 10.1113/jphysiol.2013.262246
DO - 10.1113/jphysiol.2013.262246
M3 - Journal article
C2 - 24190933
SN - 0022-3751
VL - 592
SP - 377
EP - 390
JO - The Journal of physiology
JF - The Journal of physiology
ER -