Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Maturational trajectories of white matter microstructure underlying the right presupplementary motor area reflect individual improvements in motor response cancellation in children and adolescents

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Cerebellar - premotor cortex interactions underlying visuomotor adaptation

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Accurate and robust whole-head segmentation from magnetic resonance images for individualized head modeling

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Directed connectivity between primary and premotor areas underlying ankle force control in young and older adults

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Brain-informed speech separation (BISS) for enhancement of target speaker in multitalker speech perception

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. A novel approach to localize cortical TMS effects

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. A phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK Biobank

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Cerebellar - premotor cortex interactions underlying visuomotor adaptation

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Accurate and robust whole-head segmentation from magnetic resonance images for individualized head modeling

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Maintenance of muscle strength following a one-year resistance training program in older adults

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

The ability to effectively suppress motor response tendencies is essential for focused and goal-directed behavior. Here, we tested the hypothesis that developmental improvement in the ability to cancel a motor response is reflected by maturational changes in the white matter underlying the right presupplementary motor area (preSMA) and posterior inferior frontal gyrus (IFG), two cortical key areas of the fronto-basal ganglia "stopping" network. Eighty-eight typically-developing children and adolescents, aged 7-19 years, were longitudinally assessed with the stop-signal task (SST) and diffusion tensor imaging (DTI) of the brain over a period of six years. Participants were examined from two to nine times with an average of 6.6 times, resulting in 576 SST-DTI datasets. We applied tract-based spatial statistics to extract mean fractional anisotropy (FA) from regions-of-interest in the white matter underlying the right IFG (IFGFA) and right preSMA (preSMAFA) at each time point. Motor response cancelation performance, estimated with the stop-signal reaction time (SSRT), improved with age. Initially well performing children plateaued around the age of 11 years, while initially poor performers caught up at the age of 13-14 years. White matter microstructure continued to mature across the investigated age range. Males generally displayed linear maturational trajectories, while females displayed more curvilinear trajectories that leveled off around 12-14 years of age. Maturational increases in right preSMAFA but not right IFGFA were associated with developmental improvements in SSRT. This association differed depending on the mean right preSMAFA across the individual maturational trajectory. Children with lower mean right preSMAFA exhibited poorer SSRT performance at younger ages but steeper developmental trajectories of SSRT improvement. Children with higher mean right preSMAFA exhibited flatter trajectories of SSRT improvement along with faster SSRT already at the first assessments. The results suggest that no further improvement in motor response cancellation is achieved once a certain level of maturity in the white matter underlying the right preSMA is reached. Similar dynamics may apply to other behavioral read-outs and brain structures and, thus, need to be considered in longitudinal MRI studies designed to map brain structural correlates of behavioral changes during development.

Original languageEnglish
Article number117105
JournalNeuroImage
Volume220
ISSN1053-8119
DOIs
Publication statusPublished - 15 Oct 2020

Bibliographical note

Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.

    Research areas

  • Diffusion, Longitudinal, Maturation, MRI, Response inhibition, Stop-signal task

ID: 60258953