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Matters of fiber size and myonuclear domain: Does size matter more than age?

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INTRODUCTION: The relationship between fiber size and myonuclear content is poorly understood.

METHODS: Biopsy cross-sections from young and old trained and untrained healthy individuals were analyzed for fiber area and myonuclei, and 2 fiber-size-dependent cluster analyses were performed.

RESULTS: When comparing fibers of similar size, no effect of training or age was found for myonuclear domain. There was a linear relationship between fiber area and myonuclei per fiber (r = 0.99; P < 0.001) and a non-linear relationship between fiber area and domain (r = 0.97-0.99; P < 0.0001), with a markedly smaller domain in fibers <3,000 µm(2) . A higher proportion of type II fibers <3,000 µm(2) was observed in the old subjects.

CONCLUSIONS: These findings suggest that age-related reductions in myonuclear domain size could be explained by the greater proportion of small fibers. The data also highlight the usefulness of determining fiber-size-based clusters for gaining mechanistic insight into the relationship between skeletal muscle fiber size and myonuclear content. Muscle Nerve 52: 1040-1046, 2015.

Original languageEnglish
JournalMuscle & Nerve
Volume52
Issue number6
Pages (from-to)1040-6
Number of pages7
ISSN0148-639X
DOIs
Publication statusPublished - Dec 2015

ID: 46034612