Matrix metalloproteinase-9-mediated type III collagen degradation as a novel serological biochemical marker for liver fibrogenesis

Sanne S Veidal; Efstathios Vassiliadis; Natasha Barascuk; Chen Zhang; Toni Segovia-Silvestre; Lloyd Klickstein; Martin R Larsen; Per Qvist; Claus Christiansen; Ben Vainer; Morten A Karsdal

doi:10.1111/j.1478-3231.2010.02309.x

Matrix metalloproteinase-9-mediated type III collagen degradation as a novel serological biochemical marker for liver fibrogenesis

Sanne S Veidal
, Efstathios Vassiliadis
, Natasha Barascuk
, Chen Zhang
, Toni Segovia-Silvestre
, Lloyd Klickstein
, Martin R Larsen
, Per Qvist
, Claus Christiansen
, Ben Vainer
, Morten A Karsdal

Department of Pathology

64 Citations (Scopus)

Abstract

During fibrogenesis in the liver, in which excessive remodelling of the extracellular matrix (ECM) occurs, both the quantity of type III collagen (CO3) and levels of matrix metalloproteinases (MMPs), including MMP-9, increase significantly. MMPs play major roles in ECM remodelling, via their activity in the proteolytic degradation of extracellular macromolecules such as collagens, resulting in the generation of specific cleavage fragments. These neo-epitopes may be used as markers of fibrosis.

Original language	English
Journal	Liver International
Volume	30
Issue number	9
Pages (from-to)	1293-304
Number of pages	12
ISSN	1478-3223
DOIs	https://doi.org/10.1111/j.1478-3231.2010.02309.x
Publication status	Published - 1 Oct 2010

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Veidal, S. S., Vassiliadis, E., Barascuk, N., Zhang, C., Segovia-Silvestre, T., Klickstein, L., Larsen, M. R., Qvist, P., Christiansen, C., Vainer, B., & Karsdal, M. A. (2010). Matrix metalloproteinase-9-mediated type III collagen degradation as a novel serological biochemical marker for liver fibrogenesis. Liver International, 30(9), 1293-304. https://doi.org/10.1111/j.1478-3231.2010.02309.x

Veidal, SS, Vassiliadis, E, Barascuk, N, Zhang, C, Segovia-Silvestre, T, Klickstein, L, Larsen, MR, Qvist, P, Christiansen, C, Vainer, B & Karsdal, MA 2010, 'Matrix metalloproteinase-9-mediated type III collagen degradation as a novel serological biochemical marker for liver fibrogenesis', Liver International, vol. 30, no. 9, pp. 1293-304. https://doi.org/10.1111/j.1478-3231.2010.02309.x

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title = "Matrix metalloproteinase-9-mediated type III collagen degradation as a novel serological biochemical marker for liver fibrogenesis",

abstract = "During fibrogenesis in the liver, in which excessive remodelling of the extracellular matrix (ECM) occurs, both the quantity of type III collagen (CO3) and levels of matrix metalloproteinases (MMPs), including MMP-9, increase significantly. MMPs play major roles in ECM remodelling, via their activity in the proteolytic degradation of extracellular macromolecules such as collagens, resulting in the generation of specific cleavage fragments. These neo-epitopes may be used as markers of fibrosis.",

author = "Veidal, \{Sanne S\} and Efstathios Vassiliadis and Natasha Barascuk and Chen Zhang and Toni Segovia-Silvestre and Lloyd Klickstein and Larsen, \{Martin R\} and Per Qvist and Claus Christiansen and Ben Vainer and Karsdal, \{Morten A\}",

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doi = "10.1111/j.1478-3231.2010.02309.x",

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T1 - Matrix metalloproteinase-9-mediated type III collagen degradation as a novel serological biochemical marker for liver fibrogenesis

AU - Veidal, Sanne S

AU - Vassiliadis, Efstathios

AU - Barascuk, Natasha

AU - Zhang, Chen

AU - Segovia-Silvestre, Toni

AU - Klickstein, Lloyd

AU - Larsen, Martin R

AU - Qvist, Per

AU - Christiansen, Claus

AU - Vainer, Ben

AU - Karsdal, Morten A

PY - 2010/10/1

Y1 - 2010/10/1

N2 - During fibrogenesis in the liver, in which excessive remodelling of the extracellular matrix (ECM) occurs, both the quantity of type III collagen (CO3) and levels of matrix metalloproteinases (MMPs), including MMP-9, increase significantly. MMPs play major roles in ECM remodelling, via their activity in the proteolytic degradation of extracellular macromolecules such as collagens, resulting in the generation of specific cleavage fragments. These neo-epitopes may be used as markers of fibrosis.

AB - During fibrogenesis in the liver, in which excessive remodelling of the extracellular matrix (ECM) occurs, both the quantity of type III collagen (CO3) and levels of matrix metalloproteinases (MMPs), including MMP-9, increase significantly. MMPs play major roles in ECM remodelling, via their activity in the proteolytic degradation of extracellular macromolecules such as collagens, resulting in the generation of specific cleavage fragments. These neo-epitopes may be used as markers of fibrosis.

U2 - 10.1111/j.1478-3231.2010.02309.x

DO - 10.1111/j.1478-3231.2010.02309.x

M3 - Journal article

C2 - 20666994

SN - 1478-3223

VL - 30

SP - 1293

EP - 1304

JO - Liver International

JF - Liver International

IS - 9

ER -

Matrix metalloproteinase-9-mediated type III collagen degradation as a novel serological biochemical marker for liver fibrogenesis

Abstract

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