Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Maternal serum retinol and β-carotene concentrations and neonatal bone mineralization: results from the Southampton Women's Survey cohort

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Body mass index trajectories in early childhood in relation to cardiometabolic risk profile and body composition at 5 years of age

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Investigating the effect of sex and ketosis on weight-loss-induced changes in appetite

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Is abdominal obesity at baseline influencing weight changes in observational studies and during weight loss interventions?

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Current state of evidence for endolymphatic sac surgery in Menière's disease: a systematic review

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Adolescent wine consumption is inversely associated with long-term weight gain: results from follow-up of 20 or 22 years

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Intratympanic Steroid for Menière's Disease: A Systematic Review

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

BACKGROUND: Studies in older adults and animals have suggested contrasting relations between bone health and different vitamin A compounds. To our knowledge, the associations between maternal vitamin A status and offspring bone development have not previously been elucidated.

OBJECTIVE: We examined the associations between maternal serum retinol and β-carotene concentrations during late pregnancy and offspring bone mineralization assessed at birth with the use of dual-energy X-ray absorptiometry.

DESIGN: In the Southampton Women's Survey mother-offspring birth cohort, maternal health, lifestyle, and diet were assessed prepregnancy and at 11 and 34 wk of gestation. In late pregnancy, maternal serum retinol and β-carotene concentrations were measured. Offspring total body bone mineral density (BMD), bone mineral content (BMC), and bone area (BA) were measured within 2 wk after birth.

RESULTS: In total, 520 and 446 mother-offspring pairs had measurements of maternal serum retinol and β-carotene, respectively. Higher maternal serum retinol in late pregnancy was associated with lower offspring total body BMC (β = -0.10 SD/SD; 95% CI: -0.19, -0.02; P = 0.020) and BA (β = -0.12 SD/SD; 95% CI: -0.20, -0.03; P = 0.009) but not BMD. Conversely, higher maternal serum β-carotene concentrations in late pregnancy were associated with greater total body BMC (β = 0.12 SD/SD; 95% CI: 0.02, 0.21; P = 0.016) and BA (β = 0.12 SD/SD; 95% CI: 0.03, 0.22; P = 0.010) but not BMD.

CONCLUSIONS: Maternal serum retinol and β-carotene concentrations had differing associations with offspring bone size and growth at birth: retinol was negatively associated with these measurements, whereas β-carotene was positively associated. These findings highlight the need for further investigation of the effects of maternal retinol and carotenoid status on offspring bone development.

Original languageEnglish
JournalThe American journal of clinical nutrition
Volume104
Issue number4
Pages (from-to)1183-1188
Number of pages6
ISSN0002-9165
DOIs
Publication statusPublished - Oct 2016

ID: 49175316