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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Maternal Serum Resistin Is Reduced in First Trimester Preeclampsia Pregnancies and Is a Marker of Clinical Severity

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OBJECTIVE: To examine whether resistin levels in first trimester maternal serum are associated with insulin resistance or preeclampsia (PE).

METHODS: A case-control study of maternal serum resistin concentration conducted using 285 normal pregnancies and 123 PE pregnancies matched for gestational age, parity and maternal age. Samples were taken in gestational weeks 10(+0)-13(+6).

RESULTS: There was a negative correlation between resistin and clinical severity of PE, but no correlation with IS, TNF-α, body mass index, birth weight and pregnancy length.

CONCLUSIONS: Resistin is reduced in first trimester of PE pregnancies, particularly in severe PE. Inflammation and IS cannot explain this phenomenon.

Original languageEnglish
JournalHypertension in Pregnancy
Volume34
Issue number4
Pages (from-to)422-433
ISSN1064-1955
DOIs
Publication statusPublished - 4 Dec 2015

ID: 45855957